background: motor vehicle crashes (mvc) are considered to be the most common safety challenge, causing more than a million deaths worldwide annually. objectives: the current study was aimed at identifying the etiological role of human and vehicle safety factors in road crashes, and their effects on the severity of injury and fatality in the sistan and baluchistan province, south east iran. pati...

survivors of car accidents not only are physically challenged, but also from psychological trauma, such as post-traumatic stress disorder (ptsd) also suffers. in recent years, ptsd disorder and other psychological reactions is increased after an accident. ptsd is a disorder with special signs after stressful events such as accidents can be seen psychological. ptsd is common responses that peopl...

OBJECTIVE We have previously described the generation of coxsackievirus and adenovirus receptor (α CAR)-targeted vector, and shown that intramuscular delivery in mouse leg muscles resulted in specific retrograde transduction of lumbar-motor neurons (MNs). Here, we utilized the α CAR-targeted vector to investigate the in vivo neuroprotective effects of lentivirally expressed IGF-1 for inducing n...

The notion of coarsening at random (CAR) was introduced by Heitjan and Rubin (1991) to describe the most general form of randomly grouped, censored, or missing data, for which the coarsening mechanism can be ignored when making likelihood-based inference about the parameters of the distribution of the variable of interest. The CAR assumption is popular, and applications abound. However the full...

In previous research, significant effects of weather conditions on car crashes have been found. However, most studies use monthly or yearly data and only few studies are available analyzing the impact of weather conditions on daily car crash counts. Furthermore, the studies that are available on a daily level do not explicitly model the data in a time-series context, hereby ignoring the tempora...

The nuclear receptor constitutive androstane receptor (CAR) is a key regulator for drug metabolism in liver. Human CAR (hCAR) transcripts are subjected to alternative splicing. Some hCAR splicing variants (SVs) have been shown to encode functional proteins by reporter assays. However, in vivo research on the activity of these hCAR SVs has been impeded by the absence of a valid model. This study...