This short review highlights the copper-mediated fluoroalkylation using perfluoroalkylated carboxylic acid derivatives. Carbon-carbon bond cleavage of perfluoroalkylated carboxylic acid derivatives takes place in fluoroalkylation reactions at high temperature (150-200 °C) or under basic conditions to generate fluoroalkyl anion sources for the formation of fluoroalkylcopper species. The fluoroal...

Carboxylic acids are employed as the vital starting materials in organic synthesis. Various aromatic and aliphatic carboxylic participate electrochemical decarboxylative transformations which CO2 gets liberated generate active carbocation species that reacted with various nucleophiles to produce C−C, C−N, C−O, C−S, C−halogen bonds. L. Tian, Y. Wang et al. discuss recent developments decarboxyla...

this study was carried out to investigate the effect of esterification on the surface roughness of eastern cottonwood. eastern cottonwood was modified without using any catalyst and solvent at different temperatures and times with two linear chain carboxylic acid anhydrides (acetic anhydride or propionic anhydride). different weight percentage gains (wpgs) were obtained at different conditions....

The multiconformational landscape of the proteogenic amino acid aspartic acid, the simplest amino acid with two carboxylic groups, has been explored for the first time in the gas phase. Solid aspartic acid (m.p. > 300 degrees C) was vaporized by laser ablation and expanded in a supersonic jet where rotational spectra of various conformers were obtained by Fourier transform microwave spectroscop...

The newly isolated strain Pseudomonas sp. ON-4a converts D,L-2-amino-delta2-thiazoline-4-carboxylic acid to L-cysteine via N-carbamoyl-L-cysteine. A genomic DNA fragment from this strain containing the gene(s) encoding enzymes that convert D,L-2-amino-delta2-thiazoline-4-carboxylic acid into L-cysteine was cloned in Escherichia coli. Transformants expressing cysteine-forming activity were selec...

In the title compound, C(12)H(16)O(2), the plane of the carboxylic acid group is almost perpendicular to the benzene ring [dihedral angle 80.9 (3)°] and the tert-butyl unit is disordered over two sets of sites in a 0.503 (6):0.497 (6) ratio. In the crystal structure, centrosymmetric dimers arise from pairs of O-H⋯O hydrogen bonds involving the carboxylic acid groups.

The reported structures of reaction products of enaminones with malononitrile in ethanolic piperidine are revised. A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c with nitrous acid or with benzenediazonium chloride is reported. Compounds 8a-c are converted to 1,2-dihydropyridine-3-carboxylic acid and 1,2-d...

The substituted 1,8-naphthyridines, 2-hydroxy-1,8-naphthyridine-3-carboxylic acid hydrazide (HNch) and 2-hydroxy-1,8-naphthyridine-3-carboxylic acid 0-hydroxybenzylidene hydrazide (HNCHBh) react with acetates of Mn(II), Co(II) metal ions to yield complexes of definite composition. The complexes have been characterized by elemental analysis, thermal, conductance, magnetic studies and IR, electro...

α,β-Unsaturated carboxylic acids undergo Rh(III)-catalyzed decarboxylative coupling with α,β-unsaturated O-pivaloyl oximes to provide substituted pyridines in good yield. The carboxylic acid, which is removed by decarboxylation, serves as a traceless activating group, giving 5-substituted pyridines with very high levels of regioselectivity. Mechanistic studies rule out a picolinic acid intermed...

Cyclooligomerization of 2,6-dichloropyrazine 4 and benzyl 2,3-dihydroxybenzoate 5 under microwave irradiation resulted in a racemic pair of ester functionalized ortho-linked oxacalix[2]benzene[2]pyrazine 6, which was further transformed to the corresponding racemic carboxylic acid functionalized ortho-linked oxacalix[2]benzene[2]pyrazine 3. Both enantiomers of 3 adopt 1,3-alternate conformation...