Objective: The dysregulation of metabolism is a hallmark cancer. Enzymes tricarboxylic acid (TCA) cycle have key role in pathogenesis carcinogenesis as oncometabolits. variants fumarate hydratase (FH) gene been linked to sporadic tumors and familial tumor propensity. To asses the prevalence FH endometrial carcinoma (EC) uterine leiomyomas (UL). Material Methods: This prospective study included ...

Streptococcus gallolyticus subspecies (SGG) and Fusobacterium (F.) nucleatum have been implicated in colorectal carcinogenesis. Here, the association of immune responses to bacterial exposure with advancing stages neoplasia was assessed by multiplex serology. Immunoglobulin (Ig) A G antibody eleven proteins each F. SGG were measured plasma controls (n = 100) patients cancer (CRC, n 25), advance...

Arsenic, a toxic metalloid, provokes many detrimental consequences to human health. It is prevalent in earth’s crust and poses major threat humans globally. Inorganic arsenic exposure occurs mainly via drinking water or food metabolized mammals form organic metabolites/ end products. Chronic causes lung, skin urinary bladder cancers increases the risks of liver, kidney prostate cancers. Arsenic...

Simultaneous infection with Epstein-Barr virus (EBV) and Helicobacter pylori (H. pylori) can occur. Several researchers suggested that H. would accelerate to the occurrence development of EBV-positive gastric cancer (EBV-GC). However, possible interaction in carcinogenesis is still debatable. From January 2020 December 2021, a retrospective cohort study was performed 27 patients EBV-GCs. During...

Various possible models of carcinogenesis are analyzed with respect to low dose kinetics. The importance of background carcinogenesis upon the shape of the dose-response curve at low dose is emphasized. It is shown that, if carcinogenesis by an external agent acts additively with any already ongoing process, then under almost any model the response will be linear at low dose. Measures of the de...

Abstract Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic diseases. In ovarian cancer, was identified numerous compartments, including the tumor tissue itself, upper and lower female genital tract, serum, peritoneum, intestines. Colonization linked Gram-negative bacteria with high inflammatory potential. Local inflammation probably participates initiation co...

Activation-induced cytidine deaminase (AID) plays a crucial role in promoting B cell diversification through somatic hypermutation (SHM) and class switch recombination (CSR). While AID is primarily associated with the physiological function of humoral immune response, it has also been linked to initiation progression lymphomas. Abnormalities have shown disrupt gene networks signaling pathways b...

The purpose of this report is to present recent data on two modulating factors of carcinogenesis that are found in Western-type diets: a beef-derived mutagenesis modulator that has been shown to inhibit the initiation of epidermal carcinogenesis in mice, and the possible role of net energy rather than dietary fat per se in the enhancement of rat mammary carcinogenesis.

The Twenty-Second International Symposium of the Prin cess Takamatsu Cancer Research Fund on the topic "Multi stage Carcinogenesis" was held in Tokyo. Japan, on November 19-21, 1991. The opening address was given by H. I. H. Prin cess Kikuko Takamatsu who welcomed and encouraged the invited participants to pursue a joint strategy of basic research and clinical research for cancer prevention and...