Many experiments have been described in which a batch of animals are painted or injected with a carcinogen, and the dates recorded when warts or malignant growths are detected. The object of such experiments is usually to compare the potency of different carcinogens, or of different doses or methods of application, or else to compare the sensitivity of different batches of animals to a given ca...

Methods have been developed for the detection of exposure to carcinogens and other DNA damaging agents in experimental animals and man through the detection of carcinogens or their metabolic derivatives in body fluids, or through adducts bound covalently to DNA or hemoglobin. The successful use of urinary markers of genotoxic exposures has been reported with respect to nitrosoproline as an indi...

The postulated fragmentation of RNase by N-acetoxy-2fluorenylacetamide (N-acetoxy-2-FAA), an activated metabolite of the carcinogen, N-hydroxy-24iuorenylacetamide, has been investigated. The interaction of N-acetoxy-Z-FAA with RNase resulted in the formation of two new proteins separable from RNase by electrophoresis and ion exchange chromatography. These proteins contained no new NH2terminal a...

In an earlier communication [1], carcinogenic hydrocarbons benzo(a)pyrene (BaP), 7,12-dimethylbenz(a)anthracene (DMBA) and 3-methylcholanthrene (MC) were shown to produce metaplasia and increased proliferation of the epithelium of suckling rat tracheas maintained in organ culture. Tissues exposed for several days by including hydrocarbon in the medium, and tissues so treated and then withdrawn ...

Background: Cancer is uncontrolled growth and division of cells, these cells can arise from any part the body due to exposure carcinogens, carcinogens are substance or matter that causes cancer. Breast parenchymas most vulnerable causation The prevalence breast cancer similar in both men women; prevention hazards demands early detection prompt treatment, regular curative management awareness co...

CYP1B1 is a P450 enzyme involved in activating pro-carcinogens to carcinogens as well estrogen metabolism. In order examine the effect of on cancer metabolism, it should be compared with healthy individuals and whether polymorphism between sick significant. This study aims screen CYP1B1*3 CYP1B1*4 polymorphisms group who have not been diagnosed genetic differences metabolic enzymes Turkish popu...