For cardiopulmonary bypass during open-heart surgery we use a bubble oxygenator and a technique of haemodilution and moderate hypothermia. During the course of routine perfusion we have observed arterial desaturation in a number of patients and in five patients the desaturation was marked (SaO2<85%)'. The low arterial oxygen saturations occurred mainly in the rewarming period. This report is of...

We face a profound and irreconcilable tension in the OR that is as old as the first use of heparin for cardiopulmonary bypass (CPB), 56 years ago. Our patients are treated with antiplatelet and anticoagulant drugs prior to surgery, with markedly improved short-term survival after MI and overall long-term survival. The “Wood” and “This Old House” magazines I receive every month contain 2 page ad...

Study objective: To determine if temperature during cardiopulmonary bypass (CPB) has an effect on peri¬ operative and postoperative thyroid function. Design: Prospective study comparing thyroid function duringand afterhypothermicandnormothermic CPB. Setting: Cardiac surgical unit at a university-affiliated hospital. Patients: Twelve patients scheduled to undergo car¬ diac operations with normot...

Corresponding author: Heezoo Kim, M.D., Ph.D., Department of Anesthesiology and Pain Medicine, School of Medicine, Korea University, 97, Gurodong-gil, Guro-gu, Seoul 152-703, Korea. Tel: 82-2-2626-3236, Fax: 82-2-851-9897, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.o...

BACKGROUND Coronary artery bypass surgery can be performed without (Off-Pump) or with cardiopulmonary bypass (On-Pump). Extracorporeal circulation and cardioplegic arrest may cause alterations in the plasma metabolome. We assessed metabolomic changes in patients undergoing On-Pump or Off-Pump coronary artery bypass surgery. METHODS We assessed five analyte classes (41 acylcarnitines, 14 amino...

The effect of pulsatile flow during cardiopulmonary bypass on the hormonal stress response was studied in 26 patients. Thirteen had routine and 13 had pulsatile bypass with an average pulse pressure of 30 mm Hg. Plasma vasopressin levels were significantly elevated during bypass in both groups, but were lower with pulsation (66 +/- 11 vs 36.3 pg/ml, p less than 0.05). Epinephrine levels increas...

BACKGROUND Cardiopulmonary bypass may lead to many inflammatory responses that may cause myocardial dysfunction after open heart surgery. We aimed to investigate the effect of preoperative pentoxifylline treatment to reduce the occurrence of cardiopulmonary bypass-induced inflammatory response. METHODS In a prospective, randomized study, 40 patients undergoing coronary artery bypass graft sur...

BACKGROUND To study the effect of nitecapone, a novel antioxidant, on cardiac neutrophil activation during cardiopulmonary bypass in patients. METHODS In a double-blind, placebo controlled trial, 30 male patients undergoing coronary artery bypass grafting were randomly assigned to control (crystalloid cardioplegia, n = 15) and nitecapone groups (cardioplegia supplemented with nitecapone, n = ...

Coronary artery bypass grafts relieve angina and prolong some patients' lives with an operative mortality of 1-4%. The grafting requires temporary artificial maintenance of the blood's circulation and oxygenation with cardiopulmonary bypass. In the United States some 200 000 people yearly have a coronary artery bypass graft-six times as many in relation to the population as in Britain. The grea...