Introduction: In traditional medicine, pumpkin seeds are prescribed and used commonly as energetic and sexual enhancer substances. This study was planned and carried out in order to fill the gap caused by the lack of sufficient scientific evidence on the effect of this substance on oogenesis and hormone-pituitary-ovarian axis. Revealing the effect of hydro-alcoholic extract of pumpkin seeds on ...

Carboxypeptidase E (CPE, EC 3.4.17.10) is an essential enzyme in the post-translational processing of most neuroactive peptides. We have studied how the expression of CPE in the rat retina is modified in response to the light/dark cycle. Retinal CPE mRNA levels increase immediately after a change in lighting condition. After prolonged exposure to the dark or the light, however, CPE mRNA levels ...

Sphingomyelin synthase-related protein (SMSr) synthesizes the sphingomyelin analog ceramide phosphoethanolamine (CPE) in cells. Previous cell studies indicated that SMSr is involved in ceramide homeostasis and is crucial for cell function. To further examine SMSr function in vivo, we generated Smsr KO mice that were fertile and had no obvious phenotypic alterations. Quantitative MS analyses of ...

Mice lacking Carboxypeptidase E (CPE) exhibit degeneration of hippocampal neurons caused by stress at weaning while over-expression of CPE in hippocampal neurons protect them against hydrogen peroxide-induced cell death. Here we demonstrate that CPE acts as an extracellular trophic factor to protect neurons. Rat hippocampal neurons pretreated with purified CPE protected the cells against hydrog...

the effect of different levels of wood betony (wb), stachys lavandulifolia extract, as complement in feed, on the performance of common carp, cyprinus carpio was evaluated. the fish (44±0.62 g) was assigned to four treatments, three replicates each. the fish was fed on normal diet with no wb (control) vs. diet containing 2, 4 and 8% of wb extract. fish were successively fed on the diet, 2% live...

Microcystins appear to be considered one of the most dangerous cyanobacterial toxins in world. The accumulation and change microcystins MC-LR MC-RR “cyanobacteria–cladocera–fish” food chain were studied. Microcystis aeruginosa was fed Moina macrocopa at three densities, 5.0 × 103, 105, 106 cells/mL, then passed Cyprinus flammans. total amount MCs cyanobacteria cell extract increased with increa...

Carboxypeptidase E (CPE), a prohormone processing enzyme, has been implicated in the progression of multiple malignancies. However, the biological role and molecular mechanisms of CPE in osteosarcoma remain elusive. In this study, we assessed the effects of CPE on cell proliferation, tumorigenicity, migration, and invasion in osteosarcoma. Our results showed that silencing of CPE significantly ...

In this study, the effect of ethanolic Aloe vera extract as a natural antibiotic on growth performance of common carp (Cyprinus carpio) was studied. Fish with an average weight of 29.74±1.20 g and the mean length of 11.50±0.28 cm were divided randomly into 4 treatments (a control and other groups treated with the extract of 0.1, 0.5 and 2.5% in the diet with 3 replicates and density of 10 fish ...

The current study was done to investigate the preclinical safety and toxicology of Althaea officinalis extract as naturopathic medicine in common carp (Cyprinus carpio). Specimens were treated with 0 (control), 2.5, 5 and 10 g of marshmallow extract for 45 days. Plasma biochemical parameters were measured after 15 and 45 days. Total protein, albumin and globulin levels (p < /em>>0.05). During t...

The plasma and cerebrospinal fluid pharmacokinetics of cyclopentenyl cytosine (CPE-C) were studied following i.v. bolus and continuous i.v. infusion in male rhesus monkeys. Following an i.v. bolus dose of 100 mg/m2 plasma elimination of CPE-C was biexponential with a mean t1/2 alpha of 8.4 min, a mean t1/2 beta of 36 min, and a total clearance (CLTB) of 662 ml/min/m2, which is 5- to 10-fold hig...