introduction: laryngotracheal stenosis can be caused after traumatic injuries to the neck from the subglottic larynx to the trachea. patients with laryngotracheal stenosis often need a tracheotomy and occasionally may become tracheotomy dependent. different procedures have been described for the management of these lesions. management options include techniques of endoscopic dilation, laser res...

background: recent studies have provided evidence that integrins play roles in recognition of mechanical stimuli and its translation into a cellular response. integrin signaling may be regulated by a number of mechanisms including accessory proteins such as cd98 (4f2 antigen). objectives: to determine cd98 expression by human articular chondrocytes and its involvement in human articular mechano...

Objective- Current trends emphasize the acceleration of fracture healing on the ground that in doing so, the limitation of mobility and complications associated with recovery period are reduced. The present study aims to compare autogenic costal cartilage with Chitosan scaffold in canine humeral defect healing. Design- Experimental study Animal-15 adult male dogs Procedures-...

background in rhinoplasty, functional and cosmetic problems of the nose are corrected. these problems cause imbalance between the nasal subunit and face. throughout these deformities, there are 4 variants, so there is a need for careful preoperative evaluation either for treatment or prevention of the occurrence. according to functional and aesthetic effects of these variables in rhinoplasty, e...

enrofloxacin is a synthetic chemotherapeutic agent from the class of the fluoroquinolones that is widely used to treat bacterial infections. it is metabolized to ciprofloxacin in the body as active metabolite. fluoroquinolones change in the articular cartilage, especially with high doses and more than two weeks use. so, due to relatively excessive use of enrofloxacin in mammals and similarity o...

conclusions it can be concluded that due to some bioactive and nutrient factors, mscs secretions could be used for recovery of oa as well as prevention of articular cartilage matrix degeneration, using a high dose of cell secretions. results the results revealed a decrease of proteoglycan content in the superficial and intermediate zones and presence of surface fibrillation. therefore, oa induc...

background: hyaline cartilage defects exhibit a major challenge in the field of orthopedic surgery owing to its limited repair capacity. on the other hand, mesenchymal stem cells (mscs) are regarded as potent cells with a property of cartilage regeneration. we aimed to optimize marrow-derived msc chondrogenic culture using a small bioactive molecule referred to as bio. methods: mscs from the ma...

This review summarizes the effects of the standardized proprietary bark extract of the French maritime pine (Pycnogenol®) in mild osteoarthritis (OA), stage 1 and 2. The extract exerts antioxidative, anti-inflammatory, and chondroprotective effects in vitro and in vivo. Its phenolic acids as well as catechin and taxifolin are quickly absorbed. Active metabolites, produced by gut microbiota in t...