Nitroderivatives are transformed to cyclohexylanilines at room temperature in good yields and selectivity via a hydrogenation-amine coupling cascade reaction using Pd nanoparticles on carbon as a catalyst and a Brönsted acid.

A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α.

Unprecedented synthesis of functionalized indoles of potential pharmacological interest has been developed via a Pd-mediated cascade reaction involving an intramolecular Heck coupling followed by the construction of a fused cyclopentane ring in a single pot.

Inexpensive, less-toxic ZnCl2 serves as the catalyst for selective cross-coupling of enynones and diazo compounds, an unprecedented reaction pathway for zinc carbenoids. A cascade sequence comprising formal cyclization/cross-coupling leads to a variety of 2-alkenylfurans.

Halonium-initiated cascade reaction of 1-alkenoylcyclopropane carboxamides was developed, which leads to the production of dihydrofuropyridinones and 3(2H)-furanones, respectively, depending on the property of substituents on the enone moiety.

Starting from unsaturated carbonyl compounds a mild new cascade reaction involving enolboration, rhodium-catalysed hydroformylation and intramolecular aldol addition in a regio- and diastereoselective fashion leads to cyclic compounds containing highly-functionalised quaternary carbon centres.

A novel one-pot cascade addition-cyclization-oxidation for the regioselective synthesis of furo[3,2-c]coumarins has been developed; the reaction is mild and easily handled without the necessity for dry solvents and inert atmosphere.

Rapid biocatalytic process development and intensification continues to be challenging with currently available methods. Chiral amino-alcohols are of particular interest as they represent key industrial synthons for the production of complex molecules and optically pure pharmaceuticals. (2S,3R)-2-amino-1,3,4-butanetriol (ABT), a building block for the synthesis of protease inhibitors and detoxi...

In the present work the results of analysis of the oxygen content in the water with the help of gamma-rays registration from the reaction 16O(n, p)16N is described. The samples were installed permanently on the direct beam of neutrons generated by the reaction 7Li(d, n) in the cascade generator KG-2.5 (IPPE). A comparison was carried out with experimental data obtained by the activation method ...

A comprehensive mechanistic investigation was conducted on the coupling reaction of aryl sulfoxides with phenols by using trifluoroacetic anhydride to yield biaryls. NMR experiments revealed that our previously proposed mechanism, which consists a cascade an interrupted Pummerer and rate-determining [3,3] sigmatropic rearrangement, is reasonable. The electronic effects substrates were also eval...