Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, their biosynthesis has been shown to involve several unusual enzymatic transformations. Using a combination synthesis in vitro assays we reveal that AbyV, cytochrome P450 enzyme from the aby gene cluster, catalyses key late-stage epoxidation required for installati...

Aphids are harmful agricultural insect pests that feed on the phloem sap of their hosts, infecting them with diseases. Plant-aphid interaction is a dynamic system always changing and varying. During life cycle, several aphid species change host plant. They travel between main secondary plant in spring fall. This shift has happened due to sap's nutritional importance necessity for reproduction. ...

Fumarate hydratase (FH), encoded by the FH gene, is an enzyme which catalyses conversion of fumarate to L-malate as part tricarboxylic acid cycle. Biallelic germline mutations in result fumaric aciduria, a metabolic disorder resulting severe neurological and developmental abnormalities. Heterozygous hereditary leiomyomatosis renal cell carcinoma, cancer predisposition syndrome. deficiency has m...