نتایج جستجو برای: catalytic property
تعداد نتایج: 236800 فیلتر نتایج به سال:
An approach to identify β-secretase 1 (BACE1) fragment binders that do not interact with the catalytic aspartate dyad is presented. A ThermoFluor (thermal shift) and a fluorescence resonance energy transfer enzymatic screen on the soluble domain of BACE1, together with a surface plasmon resonance (SPR) screen on the soluble domain of BACE1 and a mutant of one catalytic Asp (D32N), were run in p...
Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly concentrated in the brain where its activation by the Ca2+ sensor CaM, multivalent structure, and complex autoregulatory features make it an ideal translator of Ca2+ signals created by different patterns of neuronal activity. We provide direct evidence that graded levels of kinase activity and extent of T287 (T286α isoform) autop...
competition is against monopoly and intellectual property creates monopoly for intellectual property owner. this article had been paid cooperation between apparently contradictory policies. exhaustion, parallel imports, compulsory license, intellectual property exploitation contract that coincide with competition are methods of cooperation between intellectual property and competition law. comp...
The incredible catalytic rate enhancements caused by enzymes led Linus Pauling (1) to suggest that enzymes bind tightly to substrates distorted toward the transition state, thereby concentrating them and enforcing catalysis. Wolfenden (2) explained that chemically stable analogues that resemble the transition state would be expected to bind more tightly than substrate by factors resembling the ...
Carbon nanofibers/silver nanoparticles (CNFs/AgNPs) composite nanofibers were fabricated by two steps consisting of the preparation of the CNFs by electrospinning and the hydrothermal growth of the AgNPs on the CNFs. The as-prepared nanofibers were characterized by scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, X-ray diffraction, resonant Raman s...
The thesis of this review is that new catalytic concepts may be derived or discovered from new materials or newly recognized material properties. This thesis is demonstrated by a brief discussion of four materials, and the associated concepts, which enjoyed a certain fashion in the Journal of Catalysis and became themes of the author’s research. The four materials (or material properties) descr...
The Graded Autocatalysis Replication Domain (GARD) model described here depicts an early primordial scenario, prior to the emergence of biopolymers, such as RNA or proteins. The model describes, with the help of statistical chemistry computer simulations, a collection of organic molecular species capable of rudimentary selection and evolution. The GARD model provides a rigorous kinetic analysis...
In this study, sunlight was used for in situ preparation of gel-based various nanohybrid systems. A naturally occurring amino acid, l-phenylalanine derivative formed a hydrogel with graphene oxide (GO)/reduced graphene oxide (rGO) at physiological pH. This hydrogel was then used in the presence of silver ions and diffuse sunlight to form initially a tri-nanohybrid system consisting of six atom ...
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