In in tes t ina l mucosa of fed adult rats, cytochrome P-450 content and ac t i v i t y of benzpyrene hydroxyl ase and p-n i t roaniso le O-demethylase are highest in the upper small in test ine and progressively decrease toward the terminal ileum. Among the mucosal cell populations, mature v i l l ous t i p cel ls contain 6 to I0 times more cytochrome P-450 and drug-metabolizing ac t i v i t y...

The midgut environment of anopheline mosquitoes plays an important role in the development of the malaria parasite. Using genetic manipulation of anopheline mosquitoes to change the environment in the mosquito midgut may inhibit development of the malaria parasite, thus blocking malaria transmission. Here we generate transgenic Anopheles stephensi mosquitoes that express the C-type lectin CEL-I...

Various streptomyces strains [Streptomyces lividans 66, Streptomyces vinaceus, and Strepotmyces coelicolor A3 (2)] acquired the ability to utilize crystalline cellulose (Avicel) after transformation with a multicopy vector containing the cel-1 gene from Streptomyces reticuli. The expression level in these hosts was two to three times lower than in S. reticuli, indicating the absence of positive...

In chronic myelogenous (CML) and chronic eosinophilic leukemia (CEL), neoplastic cells spread via the circulation into various extramedullary organs. As E- and P-selectin constitute the starting point for the leucocyte adhesion/invasion cascade, and CEL and CML cells share many properties with normal granulocytes, we investigated the role of these selectins in CEL and CML cell expansion and org...

Throughout this note G denotes a discrete group. A G-complex is a CPP-complex on which G acts by cellular maps such that the fixed point set of any element of G is a subcomplex. On the category of pairs of G-complexes and equivariant homotopy classes of maps, an equivariant cohomology theory is a sequence of contravariant functors 3C into the category of abelian groups together with natural tra...

We present infrared imaging of a sample of 11 hot spots in the lobes of powerful radio galaxies. We have detected infrared counterparts to the hot spots in 3C 20West, 3C 33 South, 3C 111East and 3C 303West all of which have known optical counterparts as well. In addition, we detected the radio jet of 3C 303 in the near infrared. Four other hot spots, those in 3C 20East, 3C 65 (both sides), and ...

Archival Hubble Space Telescope WFPC2 images were used to search for optical emission associated with the radio jets of a number of luminous quasars. From this search, we report new optical hotspot detections in the wellknown blazar 3C 454.3 and the lobe-dominated quasars 3C 275.1 and 3C 336. We also find optical emission in the vicinity of the hotspot in 3C 208, but believe this is a chance al...

Recently multi-block collision attacks (MBCA) were found on the Merkle-Damg̊ard (MD)-structure based hash functions MD5, SHA-0 and SHA-1. In this paper, we introduce a new cryptographic construction called 3C devised by enhancing the MD construction. We show that the 3C construction is at least as secure as the MD construction against single-block and multi-block collision attacks. This is the f...