Fungal infections with increasing resistance to conventional therapies are a growing concern. Candida albicans is major opportunistic yeast responsible for mucosal and invasive infections. Targeting the initial step of infection process (i.e., C. adhesion host cell) promising strategy. A wide variety molecules can interfere processes via an assortment mechanisms. Herein, we focus on how small d...

The development of neurons and virtually all other cell types in the organism depends upon interactions with molecules in their environment. Studies of individual cell types have revealed tremendous diversity in the molecules that regulate the development of cells in the nervous system. These include chemotropic and trophic factors [e.g. nerve growth-factor (NGF) and brain derived neurotrophic ...

Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. We show here that JAM-L, a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. Cis dimerization of JAM-L is required to engage in heterophilic interactions with its cognate...

Current evidence indicates that tumor cell adhesion to the microvasculature in host organs during formation of distant metastases is a complex process involving various types of cell adhesion molecules. Recent results have shown that stabilization of tumor cell adhesion to the microvascular vessel wall is a very important step for successful tumor cell migration and colonization of host organs....