Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the coagulation cascade, tightly controlled by natural anticoagulants and the fibrinolytic system. Introduction Hemostasis is a defense mechanism to stop bleeding. Activated by vessel wall injury, it consists of intertwined activation of platelets and the c...

the removal of fine particles less than 2.5 μm in diameter generated from industrial plantsrepresents a serious challenge in air pollution abatement. these particles can penetrate deeply into the lungs and are difficult to remove by cyclones, electrostatic precipitators, and other conventional separation devices. in this paper, the influence of acoustic waves on removing aerosol particles from ...

heparin is frequently used in different clinical settings to reduce the coagulating ability of the blood. because of probable adverse effects owing to heparin therapy and regarding variability of patients’ responses to heparin, which make it very unreliable, it seems prudent to monitor meticulously its effects on the human body. there are a lot of laboratory tests to watch its effects on the bo...

in this work, ferric coagulation and acid cracking as olive mill wastewater (omw) pretreatments during photocatalysis process were compared in batch recirculation reactor. as ferric ions influence, ferric coagulation has preference over acid cracking. ferric ions influence on intensification of penolic components absorption on tio2 surfacein initial and oxidize organic pollutant during photocat...

OBJECTIVE Bacterial DNA (CpG DNA) persists in tissues and blood under pathological conditions that are associated with enhanced intravascular coagulation. Toll-like receptor 9 recognizes CpG DNA and elicits innate and adoptive immunity, yet the impact of CpG DNA on coagulation has not been studied. In this study, we investigated the effects of CpG DNA on the expression and activity of tissue fa...

BACKGROUND The contribution of hypercoagulability to the pathophysiology of sickle cell disease (SCD) remains poorly defined. We sought to evaluate the association of markers of coagulation and platelet activation with specific clinical complications and laboratory variables in patients with SCD. DESIGN AND METHODS Plasma markers of coagulation activation (D-dimer and TAT), platelet activatio...

Endothelial cells express several types of integral membrane protein receptors, which upon interaction and activation by their specific ligands, initiate a signalling network that links extracellular cues in circulation to various biological processes within a plethora of cells in the vascular system. A small family of G-protein coupled receptors, termed protease-activated receptors (PAR1-4), c...

BACKGROUND Sickle cell anemia is associated with a hypercoagulable state that may lead to alterations in a coagulation profile. Measurements of coagulation factors are known to have some predictive value for clinical outcome. OBJECTIVES To determine the coagulation profile of children with SCA in steady state and crisis and compare it with those with normal HbAA genotype. MATERIALS AND METH...

Abstract Hemolytic disorders characterized by complement-mediated intravascular hemolysis, such as autoimmune hemolytic anemia and paroxysmal nocturnal hemoglobinuria, are often complicated life-threatening thromboembolic complications. Severe episodes result in the release of red blood cell (RBC)-derived proinflammatory oxidatively reactive mediators (e.g., extracellular hemoglobin, heme, iron...