Abstract Extracellular signaling molecules, among them the fibroblast growth factors (FGFs), enable cells to communicate with neighboring cells. Such molecules that receive and transmit a signal require specific tyrosine kinase receptors located at cell surface (fibroblast factor receptors, FGFRs). The binding of molecule its receptor results in dimerization conformational changes cytoplasmic p...

This review touches on new insights into the possible role of Vitamin D receptors genetic polymorphisms, and steroid in patients diagnosed with breast cancer. is most common cancer women; further, it creates diverse illnesses among diseased patients, prognosis linked different subtypes present hormone receptors. Most studies focus epidemiology disease. However, fewer are done genes polymorphism...

introduction: neurotensin (nt) is a tridecapeptide that binds specifically to neurotensin receptors. several forms of cancer, including small cell lung cancer, colon, pancreatic and prostate carcinomas especially exocrine pancreatic carcinomas express receptors for neurotensin peptide. radiolabeled neurotensin derivatives with a high affinity for these receptors might be used for scintigraphy. ...

Abstract A question which has been intriguing researchers since 1969 is whether covalently linked hormones or growth factors on surfaces are still biologically active i.e. bind and activate cell surface receptors in the insoluble state. The objective of present work was to find evidence for absence any release leakage rhBMP-2 self-assembled monolayers (SAMs) prepared from dithiobis(succinimidyl...

introduction: attachment of blood and tissue cells to the extracellular matrix (ecm) is done with the help of specific joints, which are made between cells’ receptors and matrixes’ ligands. this interaction is vital for many biological activities such as cell migration, cancer development, and wound healing. the purpose of this study is to model a 3-dimensional cell by abaqus commercial softwar...

objective(s) several lines of evidence indicate that neuropeptides exhibit protective properties against gastroduodenal ulcers. neurotensin, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. in the present study, we aimed to investigate the gastroprotective potential of either per...

background : in developed or developing countries, the most common cancer in women is breast cancer with a pick in 40–50 years in asia. herein, we compared the association between ihc with fish in her2-positive breast cancer patients and affection of trastuzumab on disease free survival and overall survival (os). subjects and methods: immunohistochemical (ihc) analysis of hormone receptors and ...

conclusions the important role played by endocannabinoid system promises interesting developments, in particular to evaluate the effectiveness of new drugs in both psychiatry and neurology. materials and methods the article is a critical analysis of the most recent data currently present in scientific literature on the subject; a qualitative synthesis of only the most significant articles has b...

introduction: long-term levodopa treatment of parkinson’s disease (pd) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. the exact pathological mechanism of this complication has not yet been elucidated. we have previously demonstrated that in pd patients the vulnerability to develop peripheral but not orofacial dyskinesia is associated with th...