The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore, mandatory. Since the seminal observations two decades ago that the Tat protein, and derived peptides, can translocate across biological membr...

Antisense oligonucleotides provide a promising therapeutic approach for several disorders including cancer. Chemical stability, controlled release, and intracellular delivery are crucial factors determining their efficacy. Gels composed of nanofibrous peptide network have been previously suggested as carriers for controlled delivery of drugs to improve stability and to provide controlled releas...

Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...

background: cesarean delivery is a surgery for deliver a baby. women with previous cesarean delivery (cd) must often choose between a vaginal delivery (vd) and repeat cd. our aim of this study was to investigate factors associated with preference for cd in neyshabur pregnant women with previous cd. methods: a cross‑sectional study was conducted on all pregnant women (who had previous caesarean ...

micrornas (mirnas) represent a class of small non-coding rna molecules that regulate gene expression at the post-transcriptional level. they play a crucial role in diverse cellular pathways. ionizing radiation (ir) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. recently it has been discovered that mi...

The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to considered essential mediators intercellular communication. Their unique ability transfer macromolecules across cells and biological barriers made them rising star drug delivery. Mounting evidence suggests that EVs can be explored efficient delive...

Cytosolic protein delivery remains elusive. The inability of most proteins to cross the cellular membrane is a huge hurdle. Here we explore unique photothermal properties gold nanorods (AuNRs) trigger cytosolic proteins. Both partners, and AuNRs, are modified with protease-resistant cell-penetrating peptide nuclear targeting induce internalization. Once internalized, spatiotemporal control rele...

In this study, we were synthesized Fe3O4@LDH@Lamivudine and characterized by FT-IR spectroscopy,XRD and TEM. The interaction of this nanoparticle with CT-DNA was investigated by viscosity, circulardichroism (CD), Uv-Visible and fluorescence spectroscopy. Among all nanocarriers which applied as drugdelivery vectors, layered double hydroxides (LDHs) with exchangeable anions in t...

background: nowadays, there has been a growing trend of caesarean sections in iran. one reason would be the mother’s desire. increased maternal self‑efficacy can be an important step to reduce percentage of cesarean. this study aimed to determine the effectiveness of training‑based strategies to increase the self‑efficacy for choosing delivery method among pregnant women in shahrekord city. met...

We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver oligonucleotides into cells.