BACKGROUND Responses to neoadjuvant (before surgery) chemotherapy in locally advanced breast cancer (LABC) consist of clinical and pathological responses. Evaluating chemotherapy response is essential to predict survival rate and guide future chemotherapy. Until now, the evaluation of pathological response mainly involves quantitative assessment and is often inconsistent with clinical response....

Accurate identification of copy number alterations is an essential step in understanding the events driving tumor progression. While a variety of algorithms have been developed to use high-throughput sequencing data to profile copy number changes, no tool is able to reliably characterize ploidy and genotype absolute copy number from tumor samples that contain less than 40% tumor cells. To incre...

The central nervous system (CNS) is composed of hundreds of distinct cell types, each expressing different subsets of genes from the genome. High throughput gene expression analysis of the CNS from patients and controls is a common method to screen for potentially pathological molecular mechanisms of psychiatric disease. One mechanism by which gene expression might be seen to vary across sample...

BACKGROUND/AIMS This study aimed to determine the immunohistochemical characteristics of intramural leiomyomata that enlarged during controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF). METHODS For this retrospective case-control clinical study and immunohistochemical analysis, 5 patients with enlarged intramural leiomyomata during COH for IVF, who had undergone myomect...

Changes in structure, cellularity, hematopoietic progenitor cell and macrophage content, and osteoclast activity were investigated in the hematopoietic organs of the colony-stimulating factor l(CSF-1)-less osteopetrotic (op/op) mouse. The data indicated that op/op mice undergo an agerelated hematopoietic recovery and resolution of osteopetrosis, suggesting that the hematopoietic system has the ...

The aim of this paper is to present an answer to Problem 1 of [M1], [M2]. We do this by proving in particular that if μ is a strong limit singular cardinal, θ = (2), 2 = μ then there are Boolean algebras B1,B2 such that c(B1) = μ, c(B2) < θ but c(B1 ∗ B2) = μ. Further we improve this result, deal with the method and the neccessity of the assumptions. The research partially supported by “The Isr...

Transcellular placental maternofetal flux of calcium and magnesium is reduced in diabetic pregnancy in the rat which might be due to changes in placental cellularity. In order to investigate this wet and dry weight, DNA and protein content were measured in placentas from untreated diabetic (D(O)), insulin-treated diabetic (D(I)) and control rats (C) on day 21 of gestation (term=23 days). Wet an...

Following bone marrow transplantation, patients often suffer from immune incompetence by reduced or late T cell development. Moreover, adult bone marrow stem cells have a lower capacity to generate T cells compared with fetal liver- and umbilical cord blood-derived progenitors. Therefore, enhancing thymic-dependent T cell generation might hold great therapeutic potential. GATA-3 is a transcript...