Central nervous system (CNS) infection is associated with high rates of morbidity and mortality, despite advancements in molecular testing, aseptic meningitis remains challenging to diagnose. Aseptic cases are often underreported worldwide, which impacts the quality patient care. Therefore, we aimed assess results BioFire® FilmArray® meningitis/encephalitis (ME) PCR panel, clinical characterist...

TDC: Tunneled Dialysis Catheter; GWE: Guidewire-Directed Exchange; MSSA: Methicillin-Sensitive Staphylococcus Aureus; MRSA: Methicillin-Resistant Staphylococcus Aureus; CNS: Coagulase-Negative Staphylococcus; VREF: VancomycinResistant Enterococcus Faecalis; ABE: Acute Bacterial Endocarditis; PE: Pulmonary Embolism; DVT: Deep Vein Thrombophlebitis (Central Vein); CNS: Central Nervous System; CNI...

The principal aim of this chapter is to provide an illustrated review of the neuropathologic features of common and recently emerging central nervous system (CNS) viral diseases. An overview of the histopathologic features common to most viral infections of the central nervous system will be provided. This will be followed by a description of the gross and microscopic findings characteristic of...

INTRODUCTION Patients with immunosuppression have an increased incidence of toxoplasmosis characterized by involvement of the central nervous system. Only a few cases of toxoplasmosis associated with immunosuppressive agents have been reported. Such cases have been reported in immune suppressed patients outside the Iran, but a search of the literature has not revealed any previous reports from ...

CNS: central nervous system IHC: immunohistochemistry MMR: mismatch repair MTS: Muir-Torre syndrome M uir-Torre syndrome (MTS) is an autosomal-dominant variant of Lynch hereditary cancer syndrome. MTS is defined by sebaceous neoplasms occurring in association with 1 or more internal malignancies. The sebaceous neoplasms that characterize MTS are rare among the general population and include seb...

Primary central nervous system lymphoma (PCNSL) accounts for 1% of all lymphoma diagnoses and as many as 6% of all central nervous system (CNS) tumors. Most cases of PCNSL are of B-cell type; few are of T-cell lineage. PCNSL mainly occurs intracranially; primary spinal-cord lymphoma only occurs rarely. Moreover, intramedullary presentation without intracranial lesions is virtually unknown. Here...

Fungal infections of the central nervous system (CNS) are uncommon and occur mainly in immunocompromised patients. We describe a case of central nervous system aspergilloma without any evidence of systemic or paranasal foci in a diabetic but otherwise immunocompetent 71-year-old female treated successfully with surgical resection and medical therapy with voriconazole. Magnetic ...

The central nervous system (CNS) was once considered to be an immune-privileged area. However, increasing evidence shows that the central nervous system is not an immune-privileged but is an active surveillance site. There is a bi-directional communication between the central nervous system and immune system. Normally, immune cells migrate into the central nervous system microenvironment throug...

Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none of the recAbs showed self-reactivity upon testing with common autoantigens, they recognized 1547 proteins present on a large-scale protein microarr...