MR imaging depicted vertically oriented folia instead of the normal horizontal folial pattern, hypoplastic cerebellar vermis, fusion of the inferior posterior cerebellum, and probable polymicrogyria in the superior cerebellar hemispheres in a child with hypotonia, nystagmus, ataxia, and psychomotor retardation. We propose that this newly discovered cerebellar malformation be added to the list o...

Paraneoplastic cerebellar degeneration is an uncommon autoimmune disorder characterized clinically by progressive, ultimately incapacitating ataxia and pathologically by destruction of cerebellar Purkinje cells, with variable loss of other cell populations. The paraneoplastic cerebellar degeneration can antedate the recognition of malignancy and hence can be a warning sign for occult tumor. We ...

Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning. Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibulo-ocular reflex suggests that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the ce...

Short-survival and long-survival thymidine radiograms, and methacrylate-embedded tissue from normal and X-irradiated rat embryos were used to delineate the neuroepithelial source of the cerebellum and trace the earliest cell movements. The cerebellar anlage, crescent shaped, is demarcated by two ventricular landmarks, the anterior extension of the tela choroidea of the fourth ventricle and the ...

The anatomic diversity of the cerebellar arteriovenous malformations requires a classification which is more surgically informative. The selection tools like the Spetzler-Martin grading system are best suited for the cerebral arteriovenous malformations, while they are quite inaccurate for the cerebellar AVMs. For this reason, in order to define the subtypes of cerebellar arteriovenous malforma...

Cerebellar influence on the oculomotor evoked potential was investigated. Bilateral decerebration was performed in 25 adult cats by thalamocollicular section under chloralose anesthesia. The evoked potential in the oculomotor nucleus by the electrical stimulation of the isolated medial rectus nerve was inhibited by the repeated electrical stimulation of a restricted area of the cerebellar corte...

PURPOSE To determine the MR appearance of cerebellar abnormalities in Fukuyama congenital muscular dystrophy. METHODS We reviewed brain MR images of 25 patients with Fukuyama congenital muscular dystrophy and examined the autopsy specimens of a 23-month-old girl with the disease to determine the pathologic nature of the MR findings. RESULTS MR studies revealed two characteristic cerebellar ...

To address the regenerative capability of the differentiating hindbrain, we ablated the cerebellum in wild-type and transgenic zebrafish embryos. These larvae showed no obvious locomotive malfunction several days after the ablation. Expression analysis and in vivo time-lapse recording in GFP (green fluorescent protein)-transgenic embryos indicate that cerebellar neuronal cells can regenerate fr...

The cerebellum is densely interconnected with sensory-motor areas of the cerebral cortex, and in man, the great expansion of the association areas of cerebral cortex is also paralleled by an expansion of the lateral cerebellar hemispheres. It is therefore likely that these circuits contribute to non-motor cognitive functions, but this is still a controversial issue. One approach is to examine e...

Foxc1 mutations have been implicated in Dandy–Walker malformation (DWM), the most common human cerebellar malformation diagnosed by an enlarged posterior fossa and fourth ventricle, and cerebellar hypoplasia. Although loss of this transcription factor causes developmental cerebellar pathology, it is not expressed in the developing cerebellum. Rather it is widely expressed in embryonicmesoderman...