Alzheimer disease (AD) and cerebrovascular accidents (CVA) are the two leading causes of age-related demen-tia. The risk of AD, stroke, and CVA are known to increase at comparable rates with age. Recent advances on several fronts suggest that the vascular risk factors, which are linked to cerebrovascular disease and stroke in the elderly, significantly increase the risk of AD. Although some vas...

Reduction of blood flow to both cerebral hemispheres or the brainstem (reticular activating system), results in acute hypoperfusion. This leads to loss of consciousness and postural tone, with resulting syncope. As syncope is a transient event, it follows that the cause of central nervous system (CNS) dysfunction must also be transient. Persistent causes of significant CNS dysfunction results i...

Materials and methods Data from the Hospital Information System of SUS (Single Health System-Brazil) was accessed in the DATASUS data bank (Ministry of Health-Brazil) to allow the study of the hospitalization due to DM and also its association with the following diagnosis of the CID-10 morbidity list: renal insufficiency, cataract, glaucoma, retinal detachment, amaurosis, subnormal vision, dist...

We report the first results of simulating the coupling of neuronal, astrocyte, and cerebrovascular activity. It is suggested that the dynamics of the system is different from systems that only include neurons. In the neuron-vascular coupling, distribution of synapse strengths affects neuronal behavior and thus balance of the blood flow; oscillations are induced in the neuron-to-astrocyte coupling.

Jean-Martin Charcot (1825-1893), recognized as the founder of Neurology and the first formal teacher of nervous system diseases, died on August 16, 1893, from acute pulmonary edema secondary to myocardial infarction. In his last years, there were several descriptions of his gait and posture disorders, suggesting the diagnosis of "lower-half parkinsonism" due to cerebrovascular disease.

We report a rare association of familial cerebellar ataxia (without dementia) and cerebrovascular amyloid. Postmortem neuropathological examination of one member of the family showed amyloid angiopathy of the central nervous system with heavy infiltration of capillaries in the hippocampus and cerebellum.

Cerebellar disorders associated with HIV infection are usually caused by opportunistic infections, central nervous system lymphoma, and toxic effects of medicines, nutritional and metabolic disorders, and cerebrovascular disease. We present an unusual association of cerebellar degeneration and immune thrombocytopenic purpura in a 28-years-old woman HIV infected. An autoimmune aetiology is likely.

BACKGROUND Patients with ST-segment-elevation myocardial infarction are at increased risk of cerebrovascular events. We assessed the incidence, predictors, and implications of cerebrovascular events in patients with ST-segment-elevation myocardial infarction managed with a primary percutaneous coronary intervention strategy. METHODS AND RESULTS In the Harmonizing Outcomes With Revascularizati...