In recent years, the diagnostic capacity of colposcopy has been called into question. Recent studies have indicated that the sensitivity of this method for the detection of cervical intraepithelial neoplasia 3 (CIN 3) is between 54% and 85% [1]. In additional, it has been reported that biopsies performed under colposcopy guidance detects only two-thirds of CIN 3 lesions [2], and several researc...

Hu, X. 2001. Molecular Pathogenesis of Cervical Carcinoma: Analysis of Clonality, HPV16 Sequence Variations and Loss of Heterozygosity. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1080. 76pp. Uppsala. ISBN 91-554-5127-6 A previous model of morphological pathogenesis assumed that cervical carcinoma is of monoclonal origin and prog...

BACKGROUND As part of a project to evaluate emerging optical technologies for cervical neoplasia, our group is performing quantitative histopathological analyses of biopsy specimens from 1,190 patients. Objectives in the interim analysis are (a) quantitatively assessing progression of the neoplastic process of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesions (SIL), (b) ...

OBJECTIVES To evaluate contraceptive and reproductive risk factors for cervical intraepithelial neoplasia (CIN) in southwestern American Indian women. METHODS We conducted a clinic-based case-control study. Cases were American Indian women with biopsy-proven CIN I, CIN II or CIN III. Controls were from the same clinics and had normal cervical epithelium. All subjects underwent structured inte...

AIMS To determine the pattern of p53 immunoreactivity in cervical squamous epithelium and to investigate the relation between p53 immunostaining and human papillomavirus (HPV) infection. METHODS Immunocytochemistry for p53 was performed in 65 specimens of formalin fixed, paraffin wax embedded cervical tissue using a polyclonal antibody against recombinant p53. Microwave oven heating was used ...

OBJECTIVE The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of...

The differentiation between cervical intraepithelial neoplasia 3 (CIN 3) and early squamous cell carcinoma (SCC) of the cervix may be difficult in certain situations. Identification of invasion beyond the basement membrane is the gold standard for the diagnosis of the latter. The objective of this study was to determine whether the use of Ki-67 and p53 could help in solving the above dilemma. T...

OBJECTIVE Large studies describing the profile of high-risk Human papillomavirus (hrHPV) genotypes among women in sub-Saharan Africa are lacking. Here we describe the prevalence and distribution of hrHPV genotypes among HIV-negative women in South Africa, with and without cervical intraepithelial neoplasia (CIN). METHODS We report data on 8,050 HIV-negative women, aged 17-65 years, recruited ...

BACKGROUND Although condoms most likely prevent HIV infection, evidence of their effectiveness against other sexually transmitted diseases is mixed. GOAL The goal of the study was to determine whether condom use prevents genital human papillomavirus (HPV) infection and HPV-related conditions. STUDY DESIGN We conducted a literature review and meta-analysis of the effect of condom use on the ...