Stretch-activated channels (SACs) have been considered as one of the possible modulators on the mechanisms of mechano-electrical feedback (MEF) in the heart. With the abilities to modulate action potential duration (APD) during the systolic period and to trigger action potentials directly by diastolic stretch, SACs could play an important role on stretch-induced arrhythmias. The objective of th...

Neural circuits rely upon a precise wiring of their component neurons to perform meaningful computations. To compute the direction of motion in the visual scene, the direction selective circuit in the mouse retina depends on an asymmetry in the inhibitory neurotransmission from starburst amacrine cells (SACs) to direction selective ganglion cells (DSGCs). Specifically, depolarization of a SAC o...

Sanarelli (1891) is believed to have been the first to employ collodion sacs in animal experimentation. Subsequently, sacs of different types have been used in various in vivo experiments by a number of investigators (see bibliography). Alcohol-ether collodion was employed in each case for the preparation of the semipermeable membranes. In order to withstand the distorting effect of the intesti...

BACKGROUND Previously, we have observed that the isolated, erythrocyte-perfused rabbit heart has increased levels of heat-shock protein (HSP) 72 after a mild mechanical stress. We hypothesized that stretch-activated ion channels (SACs) mediated this increase. Methods and Results-- To test this hypothesis, we subjected isolated, perfused rat hearts to mechanical stretch. Gel mobility shift assay...

To determine whether ultrasonographic findings can predict the karyotype of spontaneous abortions, 137 pregnancies (54 spontaneous, 83 assisted ovulatory cycles) that subsequently aborted and had chromosome analysis performed on the products of conception were studied ultrasonographically. Transvaginal ultrasound was performed using an Acuson 128XP/10 with 7.5 MHz probe. The numbers of empty ge...

alpha-Fetoprotein (AFP) was shown to be the major secretory protein produced in vitro by normal rat yolk sacs. While not so active, AFP production was also detected in the transplantable tumors derived from normal yolk sacs. The major secretory protein synthesized by the tumor cells had a molecular weight of 40,000 and was reactive with an anti-rat albumin antibody. The functional messenger RNA...

MANIS, JAMES. Intestinal iron-transport defect in the mouse with sex-linked anemia. Am. J. Physiol. 220(l) : 135-139. 1971.-Everted duodenal gut sacs prepared from mice with sex-linked anemia (sZa) have a defect in the serosal transfer step of the active transport mechanism for iron that prevents the establishment of concentration gradients across the intestine greater than 1.0. The defect is p...

∗ S. Mok and K. Ong are currently Ph.D. and M.S. students of ECE at Northwestern University, Evanston, IL. Abstract An automatic method for generating assembly instructions using CAD files is presented in this paper. Algorithms for extracting geometrical information of objects stored in a non-proprietary format, ISO-10303, STEP-CAD data file are explained. The developed algorithms form an impor...

An effective technique of phase contrast synchrotron radiation computed tomography was established for the quantitative analysis of the microstructures in the respiratory zone of a mouse lung. Heitzman's method was adopted for the whole-lung sample preparation, and Canny's edge detector was used for locating the air-tissue boundaries. This technique revealed detailed morphology of the respirato...

Hypotonic cell swelling triggers an increase in intracellular Ca2+ concentration that is deemed responsible for the subsequent regulated volume decrease in many cells. To understand the mechanisms underlying this increase, we have studied the Ca2+ sources that contribute to hypotonic cell swelling-induced Ca2+ increase (HICI) in GH3 cells. Fura 2 fluorescence of cell populations revealed that e...