Tyrosinase enzymes (Tys) are involved in the key steps of melanin (protective pigments) biosynthesis and molecules targeting binuclear copper active site on tyrosinases represent a relevant strategy to regulate enzyme activities. In this work, possible synergic effect generated by combination known inhibitors is studied. For this, derivatives containing kojic acid (KA) 2-hydroxypyridine-N-oxide...

In recent years, radiometals have been successfully applied to medicine because of their breadth decay properties and increased production availability. Bifunctional chelators play a key role in radiometal-based radiopharmaceuticals, affecting the labeling, targeting, pharmacokinetics bioconjugations ensuring stable complexation metal vivo. The capacity macrocycles form complexes with extremely...