Germ cell tumors (GCTs) are a common malignancy in males, with variations differentiation making different therapeutic strategies necessary. Generally, GCTs show good curation rates due to their response radiotherapy or chemotherapy. However, certain subtypes resistant these therapies and require surgery. We present case of 25-year-old patient large retroperitoneal GCT somatic malignant transfo...

AIMS AND BACKGROUND Mediastinal radiotherapy and multiple-drug chemotherapy, including bleomycin employed in the treatment of Hodgkin's disease, can produce lung toxicity leading to fibrosis. There is increasing evidence of the involvement in the fibrosing process of different cytokines and growth factors such as TNF-alfa, IL-1 beta, TGF-beta and PDGF. MATERIAL AND METHODS In a pilot study, w...

Potential of herbs and other plant-based formulations have been increasingly recognized in prevention and treatment of human diseases including cancer. There exist enormous prospect for screening and evaluation of herbal/plant products for developing effective radiosensitization and radioprotection relevant to nuclear research program. Investigations in our laboratory have focused on the mechan...

OBJECTIVE To evaluate the functional outcomes after total laryngectomy (TLE) for a dysfunctional larynx in patients with head and neck cancer that is in complete remission after (chemo)radiotherapy. DESIGN Retrospective cohort study. SETTING Tertiary comprehensive cancer center. PATIENTS The study included 25 patients from a cohort of 217 consecutive patients with TLE who were treated bet...

Melanoma, occurring as a rapidly progressive skin cancer, is resistant to current chemo- and radiotherapy, especially after metastases to distant organs has taken place. Most chemotherapeutic drugs exert their cytotoxic effect by inducing apoptosis, which, however, is often deficient in cancer cells. Thus, it is appropriate to attempt the targeting of alternative pathways, which regulate cellul...

Combined primary small cell carcinoma and squamous cell carcinoma is a rare carcinoma of larynx of which less than 20 cases reported in the English literature. We report a case of a 62-year--old man, who presented with a history of hoarseness of his voice and dysphagia. He underwent flexible naso endoscopy which revealed a mass involving the right side of his larynx, subsequent to which he unde...

BACKGROUND There is no consensus on the therapeutic approach to poor-risk patients with unresectable stage III non-small-cell lung cancer (NSCLC), despite the increasing number of these patients in current clinical practice. In terms of survival, the combination of concurrent systemic therapy with standard radiotherapy might be advantageous over radiotherapy alone. The purpose of this review is...

When radiotherapy is used in the treatment of head and neck cancers, brain commonly receives incidental doses with potential for neurocognitive changes subsequent impact on quality life. This has not been widely investigated to date.A systematic search MEDLINE, EMBASE, Psycinfo Info Cochrane Central Register Controlled Trials (CENTRAL) electronic databases was conducted. Of 2077 records screene...

We are reporting two cases with similar appearances on post chemo radiotherapy MRI scan of the mucinous adenocarcinoma. There was high signal on T2-weighted sequences of the mucin pools within and beyond the rectal wall. Does this imply that wall tissues become less resistant to cancer pools intrusion after chemo radiation? Does the high intramural pressure have an impact on the protrusion of t...

BACKGROUND Total laryngectomy after (chemo)radiotherapy is associated with a high incidence of fistula and therefore flaps are advocated. The description of a transoral robotic total laryngectomy prompted us to develop similar minimally invasive open approaches for functional total laryngectomy. METHODS A retrospective study of consecutive unselected patients with a dysfunctional larynx after...