Treatment of chronic hepatitis B virus (HBV) infection could combine potent antiviral drugs and therapeutic vaccines to overcome immunological tolerance and induce the recovery phenotype to protect against disease progression. Conventional vaccination of woodchucks chronically infected with the woodchuck hepatitis virus (WHV) elicited differential T-cell response profiles depending on whether o...

3. Parikh SA, Kay NE, Shanafelt TD. How we treat Richter syndrome. Blood 2014;123:1647-1657. 4. Tsimberidou AM, O’Brien S, Khouri I, Giles FJ, Kantarjian HM, Champlin R, Wen S, Do KA, Smith SC, Lerner S, Freireich EJ, Keating MJ. Clinical outcomes and prognostic factors in patients with Richter’s syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantation....

We present a 64-year-old man who was treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone) chemoimmunotherapy for mantle cell lymphoma and developed purulent meningitis, probably caused by Leuconostoc sp. The patient had severe hypogammaglobulinemia, which is a possible complication of rituximab therapy. To our knowledge and after reviewing the availa...

Various chemotherapy schemes have been evaluated in SMZL. These include: chlorambucil alone, cyclophosphamide, vincristine and prednisone (CVP), or the same plus doxorrubicin (CHOP). All the mentioned schemes have limited efficacy in SMZL. The limited number of patients in these studies, as well as the selection bias (patients with advanced pathology and worse prognosis are those who undergo ch...

Various chemotherapy schemes have been evaluated in SMZL. These include: chlorambucil alone, cyclophosphamide, vincristine and prednisone (CVP), or the same plus doxorrubicin (CHOP). All the mentioned schemes have limited efficacy in SMZL. The limited number of patients in these studies, as well as the selection bias (patients with advanced pathology and worse prognosis are those who undergo ch...

Mantle cell lymphoma (MCL) is an uncommon subtype of non-Hodgkin lymphoma previously considered to have a poor prognosis. Large gains were made in the first decade of the new century when clinical trials established the importance of high-dose therapy and autologous stem-cell rescue and high-dose cytarabine in younger patients and the benefits of maintenance rituximab and bendamustine in older ...

Although there have been recent advances with targeted therapies in chronic lymphocytic leukemia (CLL), chemoimmunotherapy remains the treatment of choice; however, this approach is not curative. A key feature of CLL is that it induces a state of immunosuppression, causing increased susceptibility to infections and failure of an antitumor immune response, often worsened by the immunosuppressive...

Follicular lymphoma (FL) is the second most common type of nonHodgkin lymphoma [1]. The development of rituximab represented a major breakthrough in the management of FL, with several landmark clinical trials consistently demonstrating superior survival outcomes with rituximab-containing chemoimmunotherapies compared to chemotherapy alone, both in the frontline [2-5] and relapsed/ refractory se...