introduction: osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. yet, the toxicity of chemotherapy regimens including mtx can be life threatening. therefore; we tried another chemotherapy regimen for these patients. method and materials: we investigated 15 patients aged 15 to 40 years old a...

background: in the past 20 years, a dramatic improvement in the prognosis of patients with hepatoblastoma (hb)has been achieved by combining surgery and chemotherapy in several national and international trials.materials and methods: four children ( 3 girl and 1 boy) aged 34 days, 4 months, 13 months, and 1 year with meanage of 6.53 (±5.15) months were presented to our center from 2002 to 2009 ...

background: osteosarcoma is the most common bone sarcoma, and the third most common malignancy in children and adolescents. before 1970, amputation was the sole treatment. eighty percent of patients died from metastatic diseases, most commonly in the lungs. over the past three decades, effective neoadjuvant (preoperative) and adjuvant (postoperative) chemotherapy protocols have improved the abi...

cancer patient receive various cytotoxic drugs in association with antiemetic drugs such as 5ht3 receptor antagonists as their chemotherapy regimen. 5ht3 receptor antagonists have been reported to produce changes in ecg parameter. there are only a few studies about cardiovascular events of these drugs in patient receiving potentially cardiotoxic chemotherapies. the subject of this study is to e...

background & objective:the present study was undertaken to ascertain the incidence of early, advanced cancer cervix and its recurrence and role of chemotherapy in locally advanced cancer cervix. material and methods: the present study was conducted in the departments of obstetrics & gynaecology, pathology and radiotherapy and the specimens examined in the department of pathology of jaw...

Dilated cardiomyopathy is a frequent cause of heart failure and death. Atrial natriuretic peptide (ANP) is a biomarker of dilated cardiomyopathy, but there is controversy whether ANP modulates the development of heart failure. Therefore, we examined whether ANP affects heart failure, cardiac remodeling, function, and survival in a well-characterized, transgenic model of dilated cardiomyopathy. ...

OBJECTIVES To compare HLA distribution in familial and non-familial dilated cardiomyopathy, because a serum marker that could identify families at risk of developing dilated cardiomyopathy should be of use in screening for the disease. PATIENTS 100 patients with dilated cardiomyopathy. METHODS 200 first degree relatives from 56 of the proband families were screened for dilated cardiomyopath...

to determine the addition of value of neoadjuvant, concurrent and adjuvant chemotherapy to radiation in the treatment of nasopharyngeal carcinoma with regard to the overall survival (os) and disease free survival (dfs) within a six year period in tehran cancer institute. files of all patients with nasopharyngeal carcinoma treated by radiotherapy with or without concurrent chemotherapy in a cura...

context to review and summarize the literature regarding the current status of postchemotherapy laparoscopic retroperitoneal lymph node dissection (pcl-rplnd) in patients with testicular germ cell tumor. evidence acquisition a comprehensive review of the english literature was performed using the pubmed database using the terms “laparoscopy” or “laparoscopic”, retroperitoneal lymph node dissect...