Chronic heavy alcohol use is known to cause gut leakiness and alcoholic liver disease (ALD), but only 30% of heavy drinkers develop increased intestinal permeability and ALD. The hypothesis of this study was that disruption of circadian rhythms is a potential risk factor in actively drinking alcoholics for gut leakiness and endotoxemia. We studied 20 subjects with alcohol use disorder (AD) and ...

We are concerned with torsion subgroups of Lie groups. We extend the classical result of C. Jordan on the structure of finite linear groups to torsion subgroups of connected Lie groups. 1. In [1], Boothby and Wang proved that, for any connected Lie group G, there exists a number k{G) such that any finite subgroup contains an abelian normal subgroup whose index is bounded by k{G), thereby genera...

Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. ...

BACKGROUND Weight loss in patients with Alzheimer's disease (AD) is a common clinical manifestation that may have clinical significance. OBJECTIVES To evaluate if there is a difference between nutrition education and oral nutritional supplementation on nutritional status in patients with AD. METHODS A randomized, prospective 6-month study which enrolled 90 subjects with probable AD aged 65 ...

The cannabinoid CB1 receptor has gained much attention as a potential pharmacotherapeutic target in various neurodegenerative diseases including Alzheimer's disease (AD). However, the relation of CB1 receptors to cognitive function in AD is at present unclear. In this study, postmortem brain tissues from a cohort of prospectively assessed, neuropathologically confirmed AD patients and aged cont...

The hemilabile Ad2P(o-C6H4)NMe2 ligand promotes fast, quantitative and irreversible oxidative addition of alkynyl vinyl iodides to gold.

We prove that given a bialgebra surjection π : E → H with nilpotent kernel such that H is a Hopf algebra which is formally smooth as a K-algebra, then π has a section which is a right H-colinear algebra homomorphism. Moreover, if H is also endowed with an ad-invariant integral, then the section can be chosen to be H-bicolinear. We also deal with the dual case. As an application, we prove that e...