Anxiety-related behaviors in mice are often assessed over short periods starting immediately after introducing the animals a dedicated apparatus. In these usual conditions (5−10 min periods), cerebellar Lurcher mutants showed disinhibited characterized by abnormally high exploration of aversive areas elevated plus-maze test. We nevertheless observed that this disinhibition sharply weakened 10 m...

Previous studies have shown that the presence of hippocampal theta activity (theta) is important for learning and that the medial supramammillary nucleus (SuM) is involved in the control of the frequency of theta. In the present experiments, a single-day version (20 trials) of the Morris water maze was used to investigate the effects of drug injections into SuM on hippocampal theta frequency an...

FOWLER, S. C. Some effects of chlordiazepoxkie and chlorpromazine on response force in extinction. PHARMAC. BIOCHEM. BEHAV. 2(2) 155-160, 1974. A total of 52 male Wistar rats were continuously reinforced with food pellets for paw-pressing a silent, isometric, force-sensing manipulandum. Subsequently, extinction was introduced and the effects of chlordiazepoxide (CDP, 2.5, 5.0, 10.0 mg/kg) and c...

Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS...

佐藤 哲男 ・岩本 多喜男 ・徳光 幸子 * Though this is not a tranquillizing drug , it is used here as an antiserotonin agent. In the previous report (1), the authors showed that the brain noradrenaline level in rat was induced to elevation, in the state of electric shock, compared with that in non-treated animals. On the other hand, pretreatment with some tranquil lizing;,agents, chlorpromazine, azacyclonol inh...