UNLABELLED To clarify the spatial relationship between coronary microvascular dysfunction and myocardial fibrosis in hypertrophic cardiomyopathy (HCM), we compared the measurement of hyperemic myocardial blood flow (hMBF) by PET with the extent of delayed contrast enhancement (DCE) detected by MRI. METHODS In 34 patients with HCM, PET was performed using (13)N-labeled ammonia during hyperemia...

BACKGROUND This contribution seeks to measure preferences for health insurance in Germany and the Netherlands, using two Discrete Choice Experiments (DCE). Since the Dutch DCE was carried out right after the 2006 health reform, which made citizens explicitly choose a health insurance contract, two research questions naturally arise. First, are the preferences with regard to contract attributes ...

Multi-parametric Magnetic Resonance Imaging, and specifically Dynamic Contrast Enhanced (DCE) MRI, play increasingly important roles in detection and staging of prostate cancer (PCa). One of the actively investigated approaches to DCE MRI analysis involves pharmacokinetic (PK) modeling to extract quantitative parameters that may be related to microvascular properties of the tissue. It is well-k...

BACKGROUND Osteoarthritis (OA) is a leading cause of disability in developed nations. Total knee arthroplasty (TKA) is a clinically effective treatment for people with end-stage knee OA, and represents one of the highest volume medical interventions globally. However, up to one in three patients remain dissatisfied following TKA. Research indicates that the strongest predictor of patient dissat...

Accurate pharmacokinetic (PK) modeling of dynamic contrast enhanced MRI (DCE-MRI) in prostate cancer (PCa) requires knowledge of the concentration time course of the contrast agent in the feeding vasculature, the so-called arterial input function (AIF). The purpose of this study was to compare AIF choice in differentiating peripheral zone PCa from non-neoplastic prostatic tissue (NNPT), using P...

We examine evidence from two unique discrete choice experiments (DCE) on long term care insurance and several of its relevant attributes, more specifically, choices made by 15,298 individuals in the United States with without insurance.We study valuation following namely daily benefit, coverage, compulsory voluntary nature policy design, alongside costs (insurance premium) health requirements T...

PURPOSE: The Tofts models have long been regarded as a standard approach to tracer-kinetic analysis of DCE-MRI [1]. However, recent technological advances such as parallel imaging and higher field strengths have improved DCE-MRI data quality to a point where more complex models are required [2]. For tissues with a bidirectional exchange of tracer between intraand extravascular spaces, a number ...

Extraction constants (Kex & Kex±) for the extraction of silver picrate (AgPic) by benzo-18-crown-6 ether (B18C6) into 1,2-dichloroethane (DCE) were determined at 298 K and various ionic strength (I)-values of a water phase with or without excess HNO3. Here the symbols, Kex and Kex±, were defined as [AgLPic]DCE/P and [AgL]DCE[Pic]DCE/P with P = [Ag][L]DCE[Pic] and L = B18C6, respectively; [ ]DCE...