Animals fed cholesterol accumulate several types of cholesterol-rich lipoproteins in their plasma and ultimately develop cholesteryl ester deposition in tissue macrophages. Previous studies in the cholesterol-fed dog have shown that one class of cholesterol-rich lipoproteins, P-migrating very low density lipoproteins (P-VLDI,, density < 1.006 g/ml), possesses a unique ability to produce cellula...

A variety of substituted chiral propargylamines have been synthesized by reacting chiral N-phosphonylimines with lithium aryl/alkyl acetylides. Seventeen examples were studied to give excellent yields (>90%) and diastereoselectivities (96 : 4 to 99 : 1). It was found that the types of bases for generating acetylides and solvents are crucial for effectiveness of this asymmetric reaction. In addi...

The first generation Grubbs catalyst [Cl(2){P(C(6)H(11))(3)}(2)Ru=C(H)Ph] reacts efficiently with alkynylsilanes in the presence of water to give the styryl carbene complex [Cl(2){P(C(6)H(11))}(2) Ru=C(CH=CHPh)H] and disiloxane.

This study investigates the ability of human plasmaderived lipid transfer protein to facilitate lipid transfer to and from intact viable cells in culture. Mouse peritoneal macrophages or 5774 macrophages were preincubated with acetylated low density lipoprotein and [3H]oleate/albumin to promote the intracellular synthesis and accumulation of cholesteryl [ 3H]oleate and 3H-labeled triglyceride. ...

Adrenocortical cells were prepared from rats maintained on essential fatty acid-deficient diets and control litter mates. Cells from control rats had high concentrations of essential fatty acids in the cholesteryl ester fraction of which approximately 22% was arachidonate. In contrast, cells from EFA-deficient rats had only 2.5% arachidonate in the cholesteryl esters, even though the total este...