In the last ten years, placenta, fetal membranes (i.e. amnion and chorion), and amniotic fluid have been extensively investigated as a potential non-controversial source of stem cells. They are usually discarded after delivery and are accessible during pregnancy through amniocentesis and chorionic villus sampling [1] Several populations of cells with multi-lineage differentiation potential and ...

Transabdominal chorionic villus biopsy is an established method of obtaining material for analysing fetal chromosomes in the first trimester of pregnancy but has not been widely used for karyotyping in the second and third trimesters, when rapid results are required. The technique was evaluated in two groups of patients, comprising 106 at risk of having a fetus with chromosomal anomalies (105) ...

BACKGROUND/AIMS Tolerance of T lymphocytes at the feto-maternal interface is necessary to sustain normal pregnancy. The present investigation aimed to observe the regulatory effects on T lymphocytes by human trophoblasts and to explore possible effector molecules. METHODS Conditioned media was made by trophoblast culture or villous explant culture for T lymphocyte proliferation and proteomic ...

DNA analysis for the diagnosis of beta-thalassaemia is a relatively new technique in Malaysia. This, combined with chorionic villus sampling, has enabled us to offer prenatal diagnosis in the first trimester for this common condition. To the best of our knowledge, this has not hitherto been reported in Malaysia.

PURPOSE Amniocentesis (AC) and chorionic villus sampling (CVS) play an important role in the diagnosis of genetic anomalies. The aim of this study was to evaluate presentable numbers of procedure-related complications of genetic interventions in a tertiary referral hospital. MATERIALS AND METHODS The pregnancy outcome of women who underwent genetic AC or CVS during 2003-2010 at the Department...

Stereological methods were used to examine fibrin-type fibrinoid deposition in the intervillous spaces of human placentas collected during gestation (12-41 weeks) and from term pregnancies at low (400 m) and high (3.6 km) altitude. The main aim was to test predictions about the relationships between fibrinoid deposits and either the volume of intervillous space or the surface area of (intermedi...

INTRODUCTION The aim of this study was to examine the potential effect of chorionic villus sampling (CVS) on placental perfusion by examining the change in uterine artery pulsatility index (PI) between the first and second trimesters of pregnancy. MATERIALS AND METHODS This was a prospective screening study for pregnancy complications which included measurement of uterine artery PI at 11(+0) ...