A novel computerized program has been developed for predicting the secondary structure of proteins from their amino acid sequences. The scheme of the Chou and Fasman method (1978, Adv. Enzymol. Relat. Subj. Biochem. 47, 45-148) is closely followed. Some of their qualitative rules have been converted to numeric scales to obtain unambiguous predictions. This program has been tested on 21 proteins...

Melissa A. Clark, PhD Department of Community Health, Brown University, Program in Public Health, Providence RI The paper by Chou et al. (“Methods for measuring personal costs associated with vision impairment.”)1 in this issue of Ophthalmic Epidemiology is their second paper on this subject, now using a full year of diary data on the cost of blindness, collected in Australia. Their first paper...

Glioblastoma is the most malignant brain tumor and presents high resistance to chemotherapy radiotherapy. Surgery, radiotherapy with temozolomide are only treatments against this tumor. New targeted therapies, including epigenetic modulators such as 3‑deazaneplanocin A (DZ‑Nep; an EZH2 inhibitor) panobinostat (a histone deacetylase being tested in vitro, together temozolomide. The present study...

Design Principles dibuat untuk memodifikasi dan memformalkan pengetahuan tentang desain. Salah satu bentuk dari penerapan desain ialah dalam pembuatan User Interface/User Experience (UI/UX). sendiri bertujuan memberikan dasar aturan Penelitian ini memakai kerangka gamifikasi Octalysis yang dikembangkan oleh Yu-Kai Chou. Tujuan penelitian adalah membangun merancang aplikasi pembelajaran dengan O...

It has been a dream that theoretical biology can be extensively applied in experimental biology to accelerate the understanding of the sophiscated movements in living organisms. A brave assay and an excellent example were represented by enzymology, in which the well-established physico-chemistry is used to describe, to fit, to predict and to improve enzyme reactions. Before the modern bioinform...