The high prevalence of obesity and related metabolic diseases calls for greater understanding of the factors that drive excess energy intake. Calorie-dense palatable foods are readily available and often are paired with highly salient environmental cues. These cues can trigger food-seeking and consumption in the absence of hunger. Here we examined the effects of palatable food-paired environmen...

The Chow variety, introduced in 1937 by Chow and van der Waerden [4], parameterizes algebraic cycles of any fixed dimension and degree in a projective space, each given by its Chow form. The case of curves in IP goes back to an 1848 paper by Cayley [3]. A fundamental problem, addressed by Green and Morrison [8] as well as Gel’fand, Kapranov and Zelevinsky [6, §4.3], is to describe the equations...

INTRODUCTION The link between cardiovascular disease (CVD) and patients with chronic inflammation is not clearly understood. We examined a knock-in mouse expressing a poly-ubiquitin-binding-defective mutant of the protein ABIN1 (ABIN1(D485N)), which develops a systemic lupus erythematosus-like autoimmune disease because of the hyperactivation of IκB kinases (IκKs) and mitogen-activated protein ...

Maternal high-fat (HF) diet has long-term consequences on the metabolic phenotype of the offspring. Here, we determined the effects of postweaning exercise in offspring of rat dams fed HF diet during gestation and lactation. Pregnant Sprague-Dawley rats were maintained on chow or HF diet throughout gestation and lactation. All pups were weaned onto chow diet on postnatal day (PND) 21. At 4 wk o...

Autoantibodies to oxidized low density lipoprotein (OxLDL) are elevated in some human populations with increased risk of atherosclerosis. To determine whether autoantibody levels to epitopes of OxLDL reflect the extent of aortic atherosclerosis and the content of OxLDL, we measured IgG and IgM autoantibody titers to malondialdehyde (MDA)-LDL and copper-oxidized LDL (Cu-OxLDL) in 43 LDL receptor...

In this paper, we investigate Murre’s conjectures on the structure of rational Chow groups and exhibit explicit Chow–Künneth projectors for some examples. More precisely, the examples we study are the varieties which have a nef tangent bundle. For surfaces and threefolds which have a nef tangent bundle explicit Chow–Künneth projectors are obtained which satisfy Murre’s conjectures and the motiv...

Motivated by the Beauville–Voisin conjecture about Chow rings of powers of K3 surfaces, we consider a similar conjecture for Chow rings of powers of EPW sextics. We prove part of this conjecture for the very special EPW sextic studied by Donten–Bury et alii. We also prove some other results concerning the Chow groups of this very special EPW sextic, and of certain related hyperkähler fourfolds....

Generalizing toric varieties, we introduce toric Deligne-Mumford stacks. The main result in this paper is an explicit calculation of the orbifold Chow ring of a toric Deligne-Mumford stack. As an application, we prove that the orbifold Chow ring of the toric Deligne-Mumford stack associated to a simplicial toric variety is a flat deformation of (but is not necessarily isomorphic to) the Chow ri...

This paper concerns a solution of the smoothing problem in Chow-Rashevskii’s connectivity theorem proposed [1].

Rats offered chow, lard, and 30% sucrose solution (choice) rapidly become obese. We tested metabolic disturbances in rats offered choice, chow+lard, or chow+30% sucrose solution [chow+liquid sucrose (LS)] and compared them with rats fed a composite 60% kcal fat, 7% sucrose diet [high-fat diet (HFD)], or a 10% kcal fat, 35% sucrose diet [low-fat diet (LFD)]. Choice rats had the highest energy in...