One of the most basic observations about tickling is that one does not laugh and smile when one tries to tickle oneself. The inability to self-tickle is compelling evidence that tickling requires some factor beyond just a particular sort of physical stimulation of the ribs, feet, or other body part. However, the precise nature of the additional factor has been the subject of some debate (Harris...

BACKGROUND Kidney iron deposition (KID) is caused by iron overload that is observed in kidney diseases and anemia. The protective effects of deferoxamine (DF) and silymarin (SM) were studied against iron overload-induced KID in rat model. METHODS Rats received iron dextran (200 mg/kg) for a period of 4 weeks every other day, but at the beginning of week 3, they also were subjected to a 2-week...

Woodhall, Gavin, Christine E. Gee, Richard Robitaille, and (McBain and Dingledine 1993; Morin et al. 1996; Sah et al. Jean-Claude Lacaille. Membrane potential and intracellular Ca 1990). Interneurons of the hippocampal CA1 region receive oscillations activated by mGluRs in hippocampal stratum oriens/ major excitatory inputs from CA3 and/or CA1 pyramidal alveus interneurons. J. Neurophysiol. 81:...

We report on two young adults with KID syndrome and follicular hyperkeratosis, hidradenitis suppurativa of the groin, progressive development of proliferative pilar cysts and dissecting cellulitis of the scalp, who developed metastatic malignant pilar tumors. Based on our findings, we believe that cancer surveillance in patients with KID syndrome should include screening for pilar tumors and th...

Neuroectodermal syndromes involving the skin and inner ear may be associated with mutations in connexin proteins, which form gap junctions important for intercellular communication. Vohwinkel syndrome (keratodermia mutilans with hearing loss) and keratitis-ichthyosis-deafness (KID) syndrome are rare ectodermal dysplasias associated with dominant mutations in the GJB2 gene encoding connexin 26. ...

KID syndrome is a congenital ectodermal dysplasia characterized by the association of keratitis, hyperkeratotic skin lesions and neurosensorial hearing loss. Ocular involvement occurs in 95% of patients. Although KID syndrome cutaneous manifestations have been studied in-depth, the treatment and prognosis of ophthalmic impairment have not been described in detail. At present, the treatment of t...

GAP JUNCTIONS PROVIDE A PATHWAY for intercellular communication primarily by directly interconnecting the cytoplasm of adjacent cells (3). This pathway consists of arrays of channels, composed of proteins known as connexins. Connexin channels create a direct conduit enabling diffusion of cytoplasmic molecules, ions, and water between cells. Gap junctions thus coordinate signaling and metabolism...

this study was performed to evaluate the efficacy of injection of essential oil of eugenia caryophyllata in the kid horn buds, as a new chemical technique for disbudding. five-day-old healthy goat kids from both sexes (n = 16) were divided randomly into 4 equal groups. in groups 1, 2 and 3, 0.2 ml of clove essence and in group 4 (control) 0.2 ml of normal saline was injected into the left horn ...

Vivian Siegel is at the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA (e-mail: [email protected]) It is up to each of us to help all the Sarah Palins of this world, and all the Joe the Taxpayers behind them, understand and appreciate the value of all kinds of research, both within and beyond our borders As the Editor of a journal focused on t...