Synaptophysin is a Mr 38,000 integral membrane glycoprotein expressed by a variety of normal and neoplastic neuroendocrine cells. We studied synaptophysin as an immunocytochemical marker for neuroendocrine differentiation in lung cancer and compared it to the immunocytochemical expression of chromogranin A, a marker for dense core (endocrine) granules, and the biochemical activity of L-dopa dec...

Synaptophysin is a M, 38,000 integral membrane glycoprotein ex pressed by a variety of normal and neoplastic neuroendocrine cells. \Ve studied Synaptophysin as an immunocytochemical marker for neuroen docrine differentiation in lung cancer and compared it to the immunocy tochemical expression of chromogranin A, a marker for dense core (endocrine) granules, and the biochemical activity of i.-dop...

The granin family (Chromogranin A (CgA), 4 Chromogranin B (CgB), Secretogranin (Sg) II, and the less well studied Secretogranins III-VII) comprises a group of acidic proteins that are present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells [6, 22]. There is evidence that granins may be associated to the precursors of biologically active peptides [11, 12, 17]. ...