OBJECTIVE This paper aimed to estimate the frequency of occurrence and the types of chromosomal abnormalities found in 141 infertile men with abnormal semen parameters. METHODS the frequency and type of chromosomal abnormalities were determined with male mitotic karyotype analysis from peripheral blood through chromosome banding techniques before assisted reproduction procedures. RESULTS In...

In this study the effects of AFB1, a mold metabolite, on third instar larval salivary gland polytene chromosomes of Drosophila melanogaster were investigated. The various chromosomal abnormalities (= aberrations) as fragment loss from teminal, semibreak, asynapsis, regional shrinking, ectopic pairing on arms of polytene chromosome, were observed in polytene chromosome slides from third instar l...

OBJECTIVE To determine the association between some major structural abnormalities detected prenatally by ultrasound and chromosomal abnormalities. MATERIAL AND METHODS The present study was a retrolective, transversal study. We analyzed case records of patients during the fetal follow-up at the Department of Maternal Fetal Medicine from January 1994 to May 2010 to identify fetal patients wit...

background: the high fertilization failure after ivf treatment cycles could be related to chromosomal abnormalities. this study was carried out to assess the frequency of chromosomal abnormality on human oocytes lacking signs of fertilization 18-20 h after insemination . materials and methods: on day one, 18-20 h after insemination (ivf), fertilization was confirmed when two pronuclei (normal i...

background and objective: failure to thrive (ftt) is a sign that describes a particular problem rather than a diagnosis and explain growth failure or more advanced failure to gain weight appropriately. the aim of this study was to determine the prevalence and type of chromosomal abnormalities in patients presented with ftt. materials and method: one hundred ftt cases with clinical impression o...

Aim. Fertility disorders are one of the most common problems reproductive medicine. Chromosomal abnormalities play a crucial role in failure. The main purpose our study was to determine types and frequency chromosomal aberrations couples with history infertility. Methods. Karyotyping performed 652 failure between 2004 2022, including 203 primary infertility (PI), 240 recurrent pregnancy loss (R...

In this study the authors attempted to determine the frequency of the classical chromosomal syndromes as a cause of congenital heart disease and sought other cytogenetic abnormalities in patients with congenital heart disease, selected either for the presence of extracardiac abnormalities or the existence of congenital heart disease in other members of the family. Of the 275 patients whose kary...

In a departure from traditional gene-centric thinking with regard to cytogenetics and cytogenomics, the recently introduced genome theory calls upon a re-focusing of our attention on karyotype analyses of disease conditions. Karyotype heterogeneity has been demonstrated to be directly involved in the somatic cell evolution process which is the basis of many common and complex diseases such as c...

The frequencies of chromosomal aberrations in Giemsa-bar:ded preparations obtained from peripheral blood cultures of 5 kwashiorkor, 3 marasmic and 2 marasmickwashiorkor patients were investigated. Analysis of 1120 metaphases from these patients revealed an aberration rate of 5. 80 per cent as against a frequency of 1. 66 per cent seen in control children. However, no particular chromosome or ch...

Chromosome abnormalities in acute lymphoblastic leukemia (ALL) and their possible clinical significance are briefly re viewed based upon the literature and 60 cases studied at the University of Minnesota. Almost all cases of ALL appear to demonstrate clonal abnormalities; the major abnormal clone is usually hyperdiploid or pseudodiploid. Among cases of non-T, non-B ALL, at least four translocat...