The study of chromosome evolution is undergoing a resurgence interest owing to advances in DNA sequencing technology that facilitate the production chromosome-scale whole-genome assemblies de novo. This review focuses on history, methods, discoveries, and current challenges facing field, with an emphasis vertebrate genomes. A detailed examination literature biology rearrangements presented, spe...

800x600 years ago, it was thought that a genetic component was the fundamental cause of a number retinopathy diseases including age related macular degeneration (amd). since then, information has emerged about novel genes that contribute to various forms of amd and other retinopathies that have been eluding researchers for years. in the genetic sense, only the apoe 2 and 4 genes have been found...

background: premature chromosome condensation (pcc) is a method for interphase chromosome analysis in biodosimetry. this study was performed to verify the usefulness of pcc induced by calyculin a in human peripheral blood lymphocytes (pbl) for biological dosimetry and possible construction of dose-response curve. materials and methods: peripheral blood was obtained from a healthy donor and expo...

objective: the present retrospective study aims at identifying the prevalence of chromosomal abnormalities in a population of couples who are candidates for assisted reproductive techniques. materials and methods: cytogenetic analysis was performed according to the standard methods on cultured cells from the patients’ peripheral blood. the culture, was harvested after 72 hours. at least 20 meta...

Geneticists say a global Y-chromosome database holds profiles from men who are unlikely to have given free informed consent.

Objective: To study whether the generated CD1a positive cells belong to the leukemic cells among patients with juvenile myelomonocytic leukemia. Materials and Methods: We used mononuclear cells from 3 patients with juvenile myelomonocytic leukemia, from which two had monosomy 7. The mononuclear cells from these patients were cultured in RPMI/10%FCS without adding exogeneous growth factors fo...

Background: The advances in cytogenetic techniques during the last few years have permitted not only the study of large populations of wild and domestic animals, but also the detection of chromosome anomalies in embryos. Chromosomal abnormalities are the most common cause of embryonic and fetal mortality in mammals. Most reports of chromosome anomalies in parthenogenetic embryos describe numeri...