Case: A 51-year-old man presented with lymphadenopathy and increasing fatigue. He had been diagnosed chronic myeloid leukaemia (CML) seven months earlier a suboptimal response to first line nilotinib, failing achieve MR1 BCR-ABL1/ABL persistently >10% (IS). repeat bone marrow examination showed 90% blasts, consistent CML in blast phase (CML-BP). The blasts monoblastic morphology immunophenotype...

In order to define more clearly the role of chromosome 9 loss in head and neck squamous cell carcinoma (HNSCC), 29 invasive carcinomas and 17 preinvasive lesions were analyzed for loss of heterozygosity (LOH) on chromosome 9. We found LOH in 21 of 29 (72%) HNSCC tumors using highly polymorphic microsatellite markers. In 17 of 21, LOH was found at all informative sites on the p arm with no LOH o...

Polymorphous low-grade adenocarcinoma (PLGA) is a malignancy predominantly originating from the minor salivary glands. The molecular events underlying the pathogenesis of PLGA is poorly understood and no recurrent genetic aberrations have so far been identified. We used genome-wide, high-resolution aCGH analysis to explore genomic imbalances in 9 ...

BACKGROUND Detection of genetically-changed tumor cells in the urine is one of the new approaches for the screening of bladder carcinomas. In a previous study, numerical aberrations of chromosome 9 were found in 85.18% of bladder tumors studied by the fluorescence in situ hybridization (FISH) technique. The purpose of the present study was to investigate whether chromosome 9 aneusomy alone is a...

This tutorial reviews acoustic methods that have been used to characterize vocal function. The most persuasive argument for the use of acoustic measures is that all of the information used by listeners to make judgments about speech is to be found in the acoustic signal. Acoustic methods have been used clinically to differentiate normal from abnormal voices, to aid in differential diagnosis, to...

Determination of the chromosome base number a taxon is fundamental to understanding karyotypic variation and its implications for evolution that group. This usually requires careful evaluation cytological literature robust phylogenetic support. The family Rutaceae (x = 9 or x 18) has long been subject debate. Here, we analyzed banding pattern, rDNA sites, genome size Dictyoloma vandellianum, su...

Different ploidy levels, diploid (2n=2x=24) to hexaploid (2n=6x=72) have been reported for Acorus calamus, a perennial medicinal plant. According to available information, there is a significant relationship between the ploidy level and essential oil compositions and medicinal properties of this important genetic resource. However, there is no information about the chromosome number of A. calam...