T cell exhaustion and loss of memory potential occur during many chronic viral infections and cancer. We investigated when during chronic viral infection virus-specific CD8 T cells lose the potential to form memory. Virus-specific CD8 T cells from established chronic infection were unable to become memory CD8 T cells if removed from infection. However, at earlier stages of chronic infection, th...

Thus far, many studies have evaluated the correlation between MBL2 gene polymorphisms and hepatitis B infection. Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. There was no significant ...

conclusions the detection of mycobacterium tuberculosis is always an important differential diagnosis for skin and soft tissue involvement in endemic areas. the cold abscess is an uncommon form of cutaneous tuberculosis that can be single or multiple and with or without fistula. case presentation the case was a 42-year-old female, a known case of rheumatoid arthritis that was receiving predniso...

Hepatitis C virus (HCV), a non-cytopathic positive-stranded RNA virus, is one of the most common causes of chronic liver diseases such as chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Upon HCV infection, the majority of patients fail to clear the virus and progress to chronic hepatitis C. Chemokines are small chemotactic cytokines that direct the recruitment of immune cells a...

Toxoplasmosis has been associated with economic and public health concerns due to abortion in humans animals. Detection for the presence of anti-Toxoplasma gondii antibodies sera 174 healthy sheep (IgG) 89 aborted women (IgG, IgM, IgG avidity) using enzyme-linked immunosorbent assay T. 59 milk samples identified by PCR. The primary risk factors seropositive were also analyzed. Relatively higher...

Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18-84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patie...