INTRODUCTION Chronic inflammatory diseases, such as rheumatoid arthritis and periodontitis, cause the bone destruction by promotion of the differentiation of monocyte/macrophage lineage cells into mature osteoclasts (OCs) with active bone-resorbing character. However, the detailed mechanisms underlying this disorder remain unclear. We herein investigated the role of urokinase plasminogen activa...

Introduction Pediatric bronchial asthma has been clinically recognized as a heterogeneous disease for decades, including descriptions of patients with allergyassociated disease, viral induced asthma and exercise-induced asthma. Despite this recognition, treatment approaches were similar, involving the use of nonspecific agents, such as inhaled corticosteroids (CS) and beta 2agonists. These drug...

Backgrounds/aims Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is a chronic inflammatory disorder of the gastrointestinal tract that requires lifetime management. Many studies have attempted to establish questionnaires and/or parameters assess quality care for IBD patients. However, no study date has investigated patients using Q-methodology, which subjective been ...

Introduction: Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract. Biologic drugs target specific molecules in body’s immune system to control inflammation. Recent studies have suggested potential link between their use and an increased risk nephrolithiasis. We conducted study further investigate this association. Methods: The used multiple logistic regre...

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the airways associated with airway narrowing airflow obstruction leading to difficulty in breathing impair daily activity and cause poor quality life. Patients methods: Fifty patients whom diagnosed COPD are divided into two groups, 1st control group includes 25 assigned receive conventional therapy F...

OBJECTIVE To discuss the current clinical data on the prevalence, pathogenesis, staging, and treatment of chronic obstructive pulmonary disease (COPD). DATA SOURCES This article reviews the results of published studies and presents data from current guidelines and expert opinion. CONCLUSIONS An insidious disorder that is asymptomatic early, COPD (the preferred term for patients with chronic...

Cowden disease is an autosomal dominant disorder associated with an increased risk of breast, thyroid, and skin cancer in which germline mutations in a candidate tumour suppressor gene (PTEN) have been identified previously. Sjögren's syndrome is a chronic inflammatory and autoimmune disorder of exocrine glands for which the genetic basis is unknown. This report describes a novel PTEN mutation ...

Abstract Painful bladder syndrome/Interstitial cystitis (PBS/IC) is a chronic disorder characterized clinically by recurring episodes of pelvic pain and increased urination frequency, significantly impairing patients' quality of life. Despite this, there is an unmet medical need in terms of effective diagnostics and treatment. Animal models are crucial in this endeavor. Systemic chronic adminis...

CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-kappaB activation assays, the cytosolic CARD15 was shown to efficiently detect bacterial peptidoglycan (PGN), reminiscent of the PGN recognition protein surveillance mechanism in Drosophila. The 3 CD-associated variants and 13 additional variants carried by CD...

ABSTRACT Cigarette smoking and poor air quality are the greatest risk factors for developing chronic obstructive pulmonary disease (COPD), but growing evidence indicates that genetic also affect predisposition to clinical expression of disease. With exception α1-antitrypsin deficiency (AATD), a rare autosomal recessive disorder is present in 1–3% individuals with COPD, no single gene associated...