نتایج جستجو برای: chronotropic
تعداد نتایج: 1590 فیلتر نتایج به سال:
To assess the contribution of cardiac f2-receptors in the cardiac inotropic and chronotropic responses to a A3 agonist, terbutaline was infused (0.2 and 0.4 ,ug/kg/min), alone or after pretreatment with either oral atenolol 50 mg or atropine 0.04 mg/kg i.v. or both in six healthy subjects with a multiple crossover design. Terbutaline 0.2 ,g/kg/min increased heart rate by 15±2 beats/min, and thi...
UNLABELLED Cardiac reserve can be used to predict survival and outcome in patients with heart failure. The aim of this study was to investigate if native cardiac reserve could predict survival after myocardial infarction (MI) in mice. METHOD We investigated 27 healthy C57Bl6 mice (male symbol10-12 weeks old) with echocardiography using a high-frequency 15-MHz linear transducer. Investigations...
BACKGROUND Heart failure with preserved ejection fraction (HFpEF) has a complex etiology. Factors responsible for development of impaired exercise tolerance and disease progression are incompletely defined. OBJECTIVES The authors sought to define the contributions of contractile reserve, ventriculo-arterial coupling (VAC) reserve, and chronotropic response to the progression of HFpEF. METHO...
PURPOSE Current evidence indicates that the common AMPD1 gene variant is associated with improved survival in patients with advanced heart failure. Whilst adenosine has been recognized to mediate the cardioprotective effect of C34T AMPD1, the precise pathophysiologic mechanism involved remains undefined to date. To address this issue, we used cardio-pulmonary exercise testing data (CPX) from su...
Alzheimer disease features amyloid-β (Aβ) peptide deposition in brain and blood vessels and is associated with hypertension. Aβ peptide can cause vasoconstriction and endothelial dysfunction. We observed that Aβ peptides exert a chronotropic effect in neonatal cardiomyocytes, similar to α1-adrenergic receptor autoantibodies that we described earlier. Recently, it was shown that α1-adrenergic re...
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