Two serotonin derivatives, N,N-dimethylserotonin 5-O-β-glucoside (1a) and N-methylserotonin 5-O-β-glucoside (1b) were isolated from immature seeds of Zanthoxylum piperitum. Their structures were determined by multi-step conversion reactions and spectroscopic analyses. Immature seeds of Z. piperitum contained extremely high levels of compounds 1a and 1b of approximately 0.29% and 0.15% (w/w), re...

( ! ++ ! (+ ' + ( () %(* (+ ,* ( ./0 * * ) + , (! !1 ,! ) 2 ! ! 3 * ) * * ( + ) ( '!4 ( ' 5 ./ 6 ' + ( 7 809 ( ' : ./ 7 809 ( ' ; ! % 6 ' + ( 7 <09 ( ' = ! % 7 <09 * ( ' > ( ( ( ' 7 <01 ? + ( , ' : ->@ A B 0 ( ! -5 %/B 0 3 ! *% ! * ' ( ) 3 +( +( 3 !1 C % ( % % ! ) !! (D * ) ! !! ( * !+( % (3 + ( ,β ,β0 , ) ! 3 D % * + +( 3 !1 / ) ! * ! 3 ! * % (D * (! * E !!( (% F (%( % ! 1 ) ! (+ !! ( ,β ( % %...

In our continued efforts to explore the antidiabetic potential of pregnanes from Apocynaceae, especially Asclepiadoideae subfamily, sixteen derivatives 1-16 previously isolated various Cynanchum species, have been evaluated for their ability increase glucagon-like peptide-1 (GLP-1) release in a cell assay. As result, otophylloside A (2), wilfoside C1N (13), and C3N (16) were found stimulate sig...

In this study, we report isolation of flavonoids, viz., 3-O-methylquercetin, tangeritin, luteolin-7-O-glucoside, luteolin, apigenin-7-O-glucoside, apigenin-8-C-glucoside, luteolin-8-C-glucoside, luteolin-6-C-glucoside, diosmetin and catechin from the methanolic extract of Hyparrhenia hirta employing high performance liquid chromatography and liquid chromatography-electrospray ionization-tandem ...

A new iridoid glucoside, cornusoside A (1), and four new natural product iridoid aglycones, cornolactones A-D (2-5), together with 10 known compounds were isolated from the leaves of Cornus florida. The structures of compounds 1-5 were established by interpretation of their spectroscopic data. Cornolactone B (3) is the first natural cis-fused tricyclic dilactone iridoid containing both a five- ...

β-Glucosidases (β-D-glucoside glucohydrolases) play important role in nature, including the degradation of cellulosic biomass by fungi and bacteria, breakdown of glycolipids in mammalian lysosomes, and the cleavage of glycosylated flavonoids in plants. These enzymes have broad substrate specificity, and are used in a range of biotechnological processes. The most intensively studied area of thei...

Examination of the acetone extract of the aerial parts of Hypericum ellipticum afforded a new acetylated benzophenone glucoside (3'-O-beta-D-3",4",6"-triacetylglucopyranosyl-2,4,5',6-tetrahydroxybenzophenone) together with catechin and epicatechin. The structure of the benzophenone glucoside was determined by 2D NMR spectroscopic data. The compound inhibited the proliferation of CNS tumor cell ...

A new phenylethanoid tetraglycoside, physocalycoside (2), was isolated from the aerial parts of Phlomis physocalyx. Its structure was identified as 3-hydroxy-4-methoxy-beta-phenylethoxy-O-[alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1-->3)]-4-O-feruloyl-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranoside, on the basis of spectroscopic evidence. In addition, one known iridoid glu...