Cigarette smoking contributes to the development of pulmonary hypertension (PH) complicated with chronic obstructive pulmonary disease (COPD), and the pulmonary vascular remodeling, the structural basis of PH, could be attributed to abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs).In this study, morphometrical analysis showed that the pulmonary vessel wall thickness in sm...

smoking is known as a major cause of chronic obstructive pulmonary disease (copd) and hence immediate and effective interventions are required for its elimination. this study aimed to collect valid data with regard to cigarette smoking in adult population of north of iran for policy making by a meta-analysis of the documents of national non-communicable disease risk factors surveillance system....

background cigarette smoking is a common problem among teenagers. the aim of this study was to determine the prevalence of cigarette smoking among teen boys in marivan city, based on health belief model. materials and methods a cluster randomized sample of 470 male students with16.2±2.5   from 6 secondary schools of marivan city- iran, completed a self-report and questionnaire consisting of hea...

background the annual risk of tuberculosis (tb) in iran is about 0.5% with annual incidence rate of 23/100000 (16322 cases). different factors have been postulated as tb predisposing factors. several studies have linked smoking with pulmonary tuberculosis as the tb incidence in their adult men was 2.4 times higher than women. in iran, however, this ratio is equal and somewhere the ratio in wome...

In cigarette smoke-induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ADAM17 (A Disintegrin and Metalloprotease), is a member of the ADAM family of metalloproteases. TACE mediated ectodomain shedding leads to the conversio...

background: because of the increasing usage of waterpipe globally, we need to know more about the diff erent factors related to waterpipe and cigarette smoking. th erefore, the present study aims at gaining more insight on waterpipe and cigarette smoking based on perceived parental reaction and appeal and repellent of smoking among adolescents. materials and methods: a cross-sectional survey en...

Epidemiological studies have shown that cigarette smoke (CS), a very common environmental factor, plays an important role in skin aging. Although some in vivo studies have suggested that CS affects skin aging, the detailed effects of CS on skin cells in vitro remain largely unknown. In this study, we investigated the effects of cigarette smoke extract (CSE) on the growth, proliferation, and sen...

BACKGROUND Candidate compounds being developed to treat chronic obstructive pulmonary disease are typically assessed using either acute or chronic mouse smoking models; however, in both systems compounds have almost always been administered prophylactically. Our aim was to determine whether the prophylactic effects of reference anti-inflammatory compounds in acute mouse smoking models reflected...

Reduced vascular endothelial growth factor (VEGF) has been reported in bronchoalveolar lavage fluid and lungs of severe emphysema patients. Airway epithelial cells (AEC) are exposed to various environmental insults like cigarette smoke and bacterial infections, but their direct effect on VEGF production in well-differentiated primary human AEC remains unclear. The current authors determined the...

BACKGROUND AND OBJECTIVE Emphysema is the main pathological feature of COPD and also is the focus of the related research. Although several emphysema animal models have been established, exact comparison of findings is seldom. The present study aimed to compare cigarette smoke (CS) exposure-induced emphysema model and intraperitoneal injection of cigarette smoke extract (CSE)-induced emphysema ...