نتایج جستجو برای: cimetidine
تعداد نتایج: 1796 فیلتر نتایج به سال:
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned to Class III. Cimetidine’s therapeutic use and therapeutic index, its pharmacokinetic properties...
Fifty-four outpatients with endoscopically diagnosed benign gastric ulcer were allocated at random to treatment with either cimetidine 800 mg daily for six weeks or carbenoxolone sodium 300 mg daily for one week then 150 mg daily for five weeks. Ulcers were reassessed by endoscopy at the end of the trial. The endoscopist was unaware of the treatment and did not take part in the clinical care of...
The Zollinger-Ellison syndrome may be treated by removal of the tumour(s), total gastrectomy (Zollinger and Ellison, 1955), an H2 inhibitor, such as cimetidine (McCarthy, 1976) or a combination of these three methods. Our approach (Stadil and Stage, 1978; Welbourn and Galland, 1982) is to control the ulceration with cimetidine and then, if possible, to localize and remove the tumour. If this is...
In the paper " The comparative study of the effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in treatment of children with dyspepsia " by S. M. Dehghani et al., published in ISRN Pediatrics, Volume 2011, Article ID 219287, one sentence needs to be amended as it is incorrect or incomplete. In the abstract, in line 9, the correct sentence should read " 21.6% for Cimetidine, 43....
Cimetidine is an odourless white to off-white powder, which is sparingly soluble in water. Each Magicul tablet contains 200 mg, 400 mg or 800 mg of cimetidine. The tablets also contain maize starch, povidone, microcrystalline cellulose, sodium starch glycollate (Type A), magnesium stearate, Opadry Green OY8830 (ARTG no. 1538) for 200 mg and 800 mg tablets, and Opadry White Y-1-7000 E171 (ARTG n...
The effects of ranitidine, a new H2-receptor antagonist which does not contain an imidazole ring, and cimetidine have been determined on histamine, meal-induced gastric acid secretion, and serum gastrin levels in duodenal ulcer patients. Compared with cimetidine, ranitidine was found to be about eight times more potent an inhibitor of histamine-induced secretion and four to five times more pote...
Continuous measurement of 24 hour intragastric acidity was carried out in 30 normal volunteers during treatment with placebo, cimetidine 800 mg, ranitidine 300 mg, and famotidine 40 mg in a double blind study. Medication was taken after the evening meal (post cenam nocte, PCN). Median 24 hour acidity decreased with all H2-receptor antagonists from 25.1 mmol/l on placebo to 10 mmol/l (-60.1%) du...
In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured before and after cimetidine administration and expressed both as mean acid output ...
Cimetidine, referred as antiandrogenic agent, has caused alterations in the seminiferous tubules, including alterations in the peritubular tissue and death of myoid cells by apoptosis. Regarding the structural and functional importance of the peritubular tissue for the maintenance of Sertoli cells (SC), we purpose to investigate the SC-basement membrane interface, focusing the morphological fea...
Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was observed in 73% of patients after four weeks' treatment and in 91% after eight ...
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