Brown, R., and Pickering, D. (1974). Archives of Disease in Childhood, 49, 883. Persistent transitional circulation. Six infants presented within 24 hours of birth with cyanosis. The clinical findings, combined with catheter studies in 4 cases, led to the conclusion that there was a persistent fetal direction of ductus arteriosus flow with pulmonary hypertension, i.e. a 'persistent transitional...

Transcatheter aortic valve implantation has been associated with a higher rate of cerebrovascular events (CVEs) compared with medical treatment or surgical aortic valve replacement. This multicenter study evaluated in a large cohort of consecutive patients (n=1061) the timing, predictors, and clinical impact of CVEs after transcatheter aortic valve implantation. The incidence of 30-day CVEs was...

A 34-year-old man with a 2-year history of unexplained steroid-refractory polyneuropathy, lower-extremity edema, and monoclonal gammopathy presented to our tertiary care center with 3 days of rapidly progressive dyspnea. The patient’s vital signs were notable for a temperature of 37.0oC, heart rate of 122 bpm, blood pressure of 80/60 mm Hg, respiratory rate of 22 breaths per minute, and oxygen ...

Aim: Using conventional and novel cardiac magnetic resonance (CMR) techniques, we examined cardiac function in a cohort of late cancer survivors, previously studied with echocardiography in childhood. We compared to healthy controls, to characterize current state in the context of longitudinal functional data. Methods: 30 patients treated with anthracyclines in childhood and 19 matched controls...

This small book consists of a series of papers dealing with various aspects of hemodynamics in the macro-circulation of the lungs. The papers have little to say about the micro-circulation or the structure of the vessels themselves. Each paper is followed by a spirited discussion which proves to be a salubrious force against bias. The study group includes some of the most able and experienced i...

A 35-year-old woman with no past medical history presented to her local emergency room with 2 days of fevers, chills, and myalgias. She was febrile with a temperature of 102°F, blood pressure of 95/60 (72) mm Hg, heart rate of 110 bpm, respiratory rate of 20 breaths per minute, and an oxygen saturation of 100% on 2 L oxygen. The physical examination was notable for cool extremities, clear lungs...

A 43-year-old athletic black male was awoken from sleep with severe left-sided, nonradiating chest pain. He has no past medical history and denied any recent injury, infection, or drug use. He described the chest pain as nonreproducible on palpation but sharp that increased in severity when laying on his left side. Because of his symptoms the patient went to the local emergency department. On a...

The following articles are being highlighted as part of Circulation’s Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of cardiovascular surgery and transplantation in 2009 a...

The article by Abaci et al 1 in this issue of Circulation draws our attention to a very important and novel observation that patients with diabetes mellitus (DM) have a lesser ability to develop collateral blood vessels in the presence of coronary artery disease. This is somewhat surprising, because DM is known to stimulate angiogenesis, at least in the retina of the eye, and is, because of cap...