The continual reassessment method (CRM) enables full and efficient use of all data and prior information available in a phase I study. However, despite a number of recent enhancements to the method, its acceptance in actual clinical practice has been hampered by several practical difficulties. In this paper, we consider several further refinements in the context of phase I oncology trials. In p...

It has been shown experimentally that the vibration of a tire in the region near the contact patch can be represented by a set of decaying waves, each associated with a particular crosssectional mode. Thus, a tire can be modeled as a lossy waveguide in which decaying waves propagate in the circumferential direction. It may therefore be computationally efficient to analyze tire vibration, especi...

In this paper a new method of microwave nondestructive testing based on electromagnetic guided waves is applied to detect circumferential crack in the piping system of nuclear power plants. Microwaves as continues wave are generated by a network analyzer and amplitude of the reflection coefficient is measured by this network. For detection of any type of crack with any orientation in the pipe, ...

Several theoretical and experimental studies have shown that the characterization of a target (tube,...) can be made from the cut-off frequencies of the anti-symmetric circumferential waves A1 propagating around the tube of various radius ratio b/a (a: outer radius and b: inner radius). This work investigates the abilities of Adaptive Neuro-fuzzy Inference System ANFIS and Artificial Neural Net...

Earlier studies have shown substantial nonuniformity in normal left ventricular (LV) myocardial function concerning both the degree of shortening and timing of shortening. We hypothesized that nonuniform LV function may be related to nonuniform prestretch induced by atrial contraction. Eleven healthy human subjects were studied using MRI myocardial tagging and strain analysis. The amount of cir...

The in vivo circumferential strain has a small variation throughout the vascular system (aorta to arterioles). The axial strain has also been shown to be nearly the same as the circumferential strain under physiological loading. Since the endothelium is mechanically much softer than the media-adventitia in healthy arteries, the porcine intima was considered as a mechanically distinct layer from...