Transfer of classical conditioning to operant learning was demonstrated by showing enhanced acquisition of an operant discrimination in a group of rats (n = 6) previously exposed to pairings of the discriminative stimulus with food as compared to control animals (n = 6). A group (n = 6) that received the classical conditioning sessions while under the influence of the neuroleptic, pimozide (1.0...

The cerebellum provides a temporal computation for a number of tasks. We have found that the accuracy in timing motor responses is correlated across different motor effectors. Moreover, perceptual acuity in judging durations of auditory intervals is correlated with motoric measures of timing. These results suggest a common process underlying timing of different sorts, and that this process may ...

Addiction is increasingly discussed asa disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions towards more habitual ones. However, it remains to be investigated how acute st...

Nicotinic acetylcholine receptors (nAChRs) are essentially involved in learning and memory. A neurobiologically and behaviorally well-characterized measure of learning and memory, eyeblink classical conditioning, is sensitive to disruptions in acetylcholine neurotransmission. The two most common forms of eyeblink classical conditioning - the delay and trace paradigms - differentially engage for...

P. F. Lovibond and D. R. Shanks (2002) suggested that all forms of classical conditioning depend on awareness of the stimulus contingencies. This article considers the available data for eyeblink classical conditioning, including data from 2 studies (R. E. Clark, J. R. Manns, & L. R. Squire, 2001; J. R. Manns, R. E. Clark, & L. R. Squire, 2001) that were completed too recently to have been cons...

Using electrophysiological, biochemical, and autoradiographic techniques, changes in protein kinase C (PKC) activity in specific regions of the hippocampus have been previously implicated in classical conditioning of the nictitating membrane response of the rabbit. Here we report that activation of PKC is potentiated 2- to 3-fold in synaptosomes of the hippocampal CA1 and CA2 to -3 regions in r...