In various application areas, prior information is available about the direction of the effects of multiple predictors on the conditional response distribution. For example, in epidemiology studies of potentially adverse exposures and continuous health responses, one can typically assume a priori that increasing the level of an exposure does not lead to an improvement in the health response. Su...

Classical Hodgkin lymphoma is curable in the majority of cases with chemotherapy and/or radiation. However, 15-20% of patients ultimately relapse and succumb to their disease. Pathologically, classical Hodgkin lymphoma is characterized by rare tumor-initiating Reed-Sternberg cells surrounded by a dense immune microenvironment. However, the role of the immune microenvironment, particularly T and...

This paper examines critically the contributions of Cournot, Jevons and Walras as the founders of classical mathematical economics from a methodological standpoint. Advances in different economic schools and doctrines in the 19th century produced an environment of multi-dimensionality in economic analysis which was regarded by the pioneers of classical mathematical economists as a chaotic state...

‎Several modifications of the Laplace distribution have been introduced and applied in various fields up to this day‎. ‎In this paper‎,  ‎we introduce a modified symmetric version of the classical Laplace distribution‎.  ‎We provide a comprehensive theoretical description of this distribution‎. ‎In particular‎, ‎we derive the formulas for th...

Epstein-Barr virus (EBV) is involved in numerous lymphoproliferative diseases. In addition to classical lesions such as endemic Burkitt's lymphoma and infectious mononucleosis, there are other disorders of the lymphoid system that are discussed in relation to EBV: B-cell lymphomas in immunosuppressed individuals. Hodgkin's disease and, to some extent, primary extranodal lymphomas. Studies of th...

According to the World Health Organization (WHO) 2008 criteria, MPNs are now divided in classical MPNs which carry the Philadelphia (Ph+) chromosome (chronic myeloid leukaemia) and classical MPNs which do not carry the Philadelphia (Ph-) chromosome, including essential thrombocythemia, polycythemia vera, primary myelofibrosis, chronic neutrophilic leukemia, chronic eosinophilic leukemia, mastoc...

Accumulation of classical monocytes is imperative for the progression of atherosclerosis. Hence, therapeutic interference with mechanisms of lesional monocyte recruitment, the primary mechanism controlling macrophage accumulation, may allow for targeting atheroprogression and its clinical complications. Here, we review the important role of classical monocytes in atheroprogression as well as th...

This paper modifies Kak’s three-stage protocol so that it can guarantee secure transmission of information. Although avoiding man-in-the-middle attack is our primary objective in the introduction of classical authentication inside the three-stage protocol, we also benefit from the inherent advantages of the chosen classical authentication protocol. We have tried to implement ideas like key dist...