Current therapy for BCL-2-associated tumors such as Non-Hodgkin Lymphomas (NHL) is inadequate. The DNAi PNT2258, a 24 base single-stranded phosphodiester DNA oligodeoxynucleotide (PNT100) encapsulated in a protective liposome, was precisely designed to treat cancers that over-express BCL-2. PNT2258 strongly inhibited BCL-2 promoter activity, confirming its predicted mechanism of action. BCL-2 m...

marginal zone lymphoma (mzl) accounts for between 5% and 17% of all non-hodgkin lymphomas (nhl). w e reported a rare case of marginal zone lymphoma presenting with bilateral ear erythema and swelling. the case was a 79-year-old man who suffered from progressive bilateral ear erythema and swelling since 2 years ago. physical examination was remarkable for erythmatous, edematous and non-tender au...

Ten patients with low grade non-Hodgkin's lymphoma (seven follicular small cleaved and three small lymphocytic) were treated with 1 microgram oral alfacalcidol (1 alpha-hydroxycholecalciferol) daily. Of the seven patients with lymphomas of follicular small cleaved subtype, one achieved complete and three partial remission, whereas none of three patients with small lymphocytic lymphomas responde...

purpose: to report a case of lacrimal sac lymphoma presenting with nasolacrimal obstruction. patient and findings: a 35-year-old woman presented with epiphoria and swelling of the left lacrimal sac area and cervical lymphadenopathy. she had undergone dacryocystorhinostomy (dcr) 6 months before. computed tomography demonstrated a lacrimal sac mass involving the nasal cavity. histopathologic exam...

Natural and synthetic triterpenoids have been shown to kill cancer cells via multiple mechanisms. The therapeutic effect and underlying mechanism of the synthetic triterpenoid bardoxolone methyl (C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; CDDO-Me) on esophageal cancer are unclear. Herein, we aimed to investigate the anticancer effects and underlying mechanisms of CDDO-Me...

the occurrence of langerhans cell histiocytosis (lch) in a patient with lymphoma is an indication of a probable relationship between them. the two conditions have similarities both clinically and histopathologically. occurrence of these two conditions in the same patient, particularly not simultaneously, is rare. according to different management and treatment of these conditions, exact histopa...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...

Epigenetic code modifications by histone deacetylase inhibitors (HDACis) have recently been proposed as potential new therapies for hematological malignancies. Diffuse large B-cell lymphoma (DLBCL) is the most common form of aggressive lymphoma. At present, standard first line treatment for DLBCL patients is the antracycline-based chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincri...

Liquiritigenin (LQ), separated from Glycyrrhiza radix, possesses anti-inflammatory, antihyperlipidemic, and antiallergic effects. Our present study aims to investigate the antihepatocellular carcinoma effects of LQ both in cell and animal models. LQ strikingly reduced cell viability, enhanced apoptotic rate, induced lactate dehydrogenase over-release, and increased intracellular reactive oxygen...