BACKGROUND AND PURPOSE Adequate outcome assessment is crucial to randomized trials. We wished to assess the types of outcomes used in acute stroke trials and the appropriateness of these outcomes and their analyses. METHODS Acute stroke trials from the Cochrane Stroke Group's database were included from 1955 to 1995 if they were published in full text in English. For each trial we collected y...

BACKGROUND The Melbourne Assessment of Unilateral Upper Limb Function is a valid tool for measuring quality of upper-limb movement in children ages 5 to 15 with cerebral palsy. This study presents the first phase in establishing the validity of a modified version of the assessment for children ages 2 to 4. OBJECTIVE We sought to determine whether children without neurological impairment score...

The current guidelines for the diagnosis and treatment of hypertension recommend screening for cognitive impairment in all hypertensive patients as part of the clinical assessment. However, the implementation of this recommendation in clinical practice is still unsatisfactory. We present the case of an elderly hypertensive female patient in order to highlight the importance of screening for cog...

Background: Sentence repetition is gaining increasing attention as a source of information about children’s sentence-level abilities in clinical assessment, and as a clinical marker of Specific Language Impairment. However, it is widely debated what the task is testing and therefore how informative it is. Aims: The study aims to: i) evaluate the effects of different types of long-term linguisti...

INTRODUCTION There are no blood-based biomarkers for cognitive decline in aging, or mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cumulative evidence suggests that apolipoproteins, complement system, and transthyretin are involved in AD pathogenesis by sequestration of amyloid β. However, there is no clinical study to assess the utility of "sequester proteins" in risk assessment...

We present an end-to-end system for automatically scoring spoken responses to a narrative recall test administered to seniors when screening for cognitive impairment. In Wechsler Logical Memory (WLM) test, a patient listens to a brief narrative, then retells the story once immediately and again after a brief delay. We transcribe the retellings automatically using an ASR system, align the transc...

Bulbar motor deterioration due to amyotrophic lateral sclerosis (ALS) leads to the eventual impairment of speech and swallowing functions. Despite these devastating consequences, no standardized diagnostic procedure for assessing bulbar dysfunction in ALS exists and adequate objective markers of bulbar deterioration have not been identified. In this paper, we consider objective measures of spee...

Aim To assess the sensitivity and specificity of automated movement recognition in predicting motor impairment high-risk infants. Method We searched MEDLINE, Embase, PsycINFO, CINAHL, Web Science, Scopus databases identified additional studies from references relevant studies. included that evaluated infants to predict impairment, including cerebral palsy (CP) non-CP impairments. Two authors in...