Clinical pathways are complex processes based on knowledge and personal experience, which are essential for high quality patient treatment. However, the insufficient knowledge coverage and representation for detailed clinical pathways makes it difficult to provide accurate information to improve patient safety. The gap between the dynamic practical treatment process and the predefined clinical ...

Background Neoplastic adenomatous polyps generating from the epithelial cells are considered benign tumors. Adenomatous polyps are common in western countries and it can take seven to 10 or more years for an adenoma to evolve into cancer.  The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the r...

BACKGROUND Although asthma clinical pathways are used with increasing frequency, few controlled studies have evaluated the clinical and cost effectiveness of these pathways. OBJECTIVE To evaluate the effect of an inpatient asthma clinical pathway on cost and quality of care for children with asthma. METHODS One hundred forty-nine children were treated for status asthmaticus using an asthma ...

Abstract Hypoxia is an essential topic in medical or biological sciences. The main aims of the present study were to examine most important articles (i.e., top 100 cited) on hypoxia. We how Nobel-prize awarded hypoxia inducible factor (HIF)-pathway discovery early 1990s has changed thematic composition this body literature, with a special emphasis studies linking and cancer. searched Pubmed for...

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

Background To investigate the role of the anti-Müllerian hormone (AMH) signalling pathway in the pathophysiology of idiopathic primary ovarian insufficiency (POI) and age at natural menopause (ANM) using a genetic approach MaterialsAndMethods DNA sequencing was used to detect the genotype distribution and allele frequency of the genes AMH and AMH receptor II (AMHR2) in 120 cases of idiopathic P...

Effective cancer therapy requires identification of signaling networks and investigating their potential role in proliferation invasion cells. Among molecular pathways, signal transducer activator transcription 3 (STAT3) has been importance due to its involvement promoting proliferation, cells, mediating chemoresistance. In the present review, our aim is reveal STAT3 pathway bladder (BC), as on...